Early hypocarbia of pretern infants: Its relationship to periventricular leukomalacia and cerebral palsy, and its perinatal risk factors
Early hypocarbia of pretern infants: Its relationship to periventricular leukomalacia and cerebral palsy, and its perinatal risk factors
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DOI：
10.1080/08035250410033015
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发表时间：
2005-01-01
期刊：
影响因子：
3.8
通讯作者：
Ishida, A
中科院分区：
文献类型：
--
作者：
Murase, M;Ishida, A
目的：探讨早期低碳血症、脑室周围白质软化症（PVL）与早产儿脑瘫的临床相互作用。方法：对1995 ~ 1999年间收治的115例极低出生体重儿分别在出生后3、6、12、24、48 h进行动脉血PaCO2测定。严重的早期低碳血症。在8名婴儿（低碳组）中观察到，当5个PaCO2值中至少有2个显示3.3 kPa或更低时定义。通过连续超声检查和颅磁共振成像诊断早产儿PVL。并将其分为14 d内诊断的早发性PVL和14 d后诊断的晚发性PVL。通过母亲的记录和产科医生的访谈调查早期低碳血症的围产期危险因素。结果：低碳组新生儿平均出生体重明显小于对照组(p
Aim: To clarify clinical interactions between early hypocarbia, periventricular leukomalacia (PVL) and cerebral palsy of preterm infants. Methods: Serial measurements of PaCO2 using arterial blood samples at 3, 6, 12, 24 and 48 h of life were performed for 115 very-low-birthweight infants admitted between 1995 and 1999. Severe early hypocarbia. defined when at least two of five PaCO2 values showed 3.3 kPa or less, was observed in eight infants (hypocarbia group). Preterm PVL was diagnosed by serial ultrasonographic examinations and cranial magnetic resonance imaging. and subsequently classified into early-onset PVL diagnosed within 14 d, or late-onset PVL after 14 d. Perinatal risk factors for early hypocarbia were investigated from the mothers' records and interviews with obstetricians. Results: The average birthweight in the hypocarbia group was significantly smaller than that in the control group (p