Collectin 11 has a pivotal role in host defense against kidney and bladder infection in mice
Collectin 11 has a pivotal role in host defense against kidney and bladder infection in mice
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DOI：
10.1016/j.kint.2023.11.031
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Li Ke
中科院分区：
文献类型：
--
作者：
Wu Kunyi;Cao Bo;Chen Wanbing;Wu Weiju;Zhao Shujuan;Min Xiaoyun;Yang Jurong;Han Jin;Dong Xia;Wang Na;Wu Yi;Garred Peter;Sacks Steven H;Zhou Wuding;Li Ke
The urinary tract is constantly exposed to microorganisms. Host defense mechanisms in protection from microbial colonization and development of urinary tract infections require better understanding to control kidney infection. Here we report that the lectin collectin 11 (CL-11), particularly kidney produced, has a pivotal role in host defense against uropathogen infection. CL-11 was found in mouse urine under normal and pathological conditions. Mice with global gene ablation of Colec11 had increased susceptibility to and severity of kidney and to an extent, bladder infection. Mice with kidney-specific Colec11 ablation exhibited a similar disease phenotype to that observed in global Colec11 deficient mice, indicating the importance of kidney produced CL-11 for protection against kidney and bladder infection. Conversely, intravesical or systemic administration of recombinant CL-11 reduced susceptibility to and severity of kidney and bladder infection. Mechanism analysis revealed that CL-11 can mediate several key innate defense mechanisms (agglutination, anti- adhesion, opsonophagocytosis), and limit local inflammatory responses to pathogens. Furthermore, CL-11-mediated innate defense mechanisms can act on clinically relevant microorganisms including multiple antibiotic resistant strains. CL-11 was detectable in eight of 24 urine samples from patients with urinary tract infections but not detectable in urine samples from ten healthy individuals. Thus, our findings demonstrate that CL-11 is a key factor of host defense mechanisms in kidney and bladder infection with therapeutic potential for human application.
