Auxiliary functions in photosynthesis: the role of the FtsH protease
Auxiliary functions in photosynthesis: the role of the FtsH protease
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DOI：
10.1042/bst0290455
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发表时间：
2001-08-01
影响因子：
3.9
通讯作者：
Mann, N
中科院分区：
文献类型：
--
作者：
Bailey, S;Silva, P;Mann, N
含氧光合作用可以有效地描述使用两个长期存在的模型：Z-计划和化学渗透假说。然而，这些模型并没有揭示类囊体膜和它所结合的四个主要复合物的动态性质。光合机构的组成是不断变化的，以响应一系列的环境刺激。此外，许多光合作用组分在自然界中具有最高的周转率。光合组分的组成和周转的变化需要现有的和受损的多肽的降解和新的多肽及其相关辅因子的再合成和协调组装。这是通过几种辅助功能实现的，包括蛋白水解、蛋白质靶向和分子伴侣的作用。参与这些功能的一些组分，如translocons，分子伴侣和蛋白酶，已被确定，但光合作用的许多辅助功能仍然没有特征。在已知与类囊体相关的蛋白酶中，锌金属蛋白酶FtsH也可能充当伴侣。在这里，我们提供了一个概述的类囊体FtsH蛋白酶，并讨论其在维护和组装的光合机构的作用。
Oxygenic photosynthesis can be described effectively by using two long-standing models: the Z-scheme and the chemiosmotic hypothesis. However, these models do not reveal the dynamic nature of the thylakoid membrane and the four major complexes that it binds. The composition of the photosynthetic apparatus is continually changing in response to a range of environmental stimuli. In addition, many photosynthetic components have some of the highest turnover rates in Nature. Changes in composition and turnover of photosynthetic components require the degradation of existing and damaged polypeptides and the resynthesis and co-ordinated assembly of new polypeptides and their associated cofactors. This is achieved by several auxiliary functions, including proteolysis, protein targeting and the action of molecular chaperones. Some of the components involved in these functions, such as translocons, chaperones and proteases, have been identified but many of the auxiliary functions of photosynthesis remain uncharacterized. Among the proteases known to be associated with the thylakoids is the zinc metalloprotease FtsH, which might also act as a chaperone. Here we provide an overview of the thylakoid FtsH protease and discuss its role in the maintenance and assembly of the photosynthetic apparatus.