Stroke genomics in people of African ancestry: charting new paths.
Stroke genomics in people of African ancestry: charting new paths.
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DOI：
10.5830/cvja-2015-039
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发表时间：
2015-03
影响因子：
0.7
通讯作者：
SIREN Investigators as Members of the H3Africa Consortium
中科院分区：
文献类型：
--
作者：
Akinyemi RO;Ovbiagele B;Akpalu A;Jenkins C;Sagoe K;Owolabi L;Sarfo F;Obiako R;Gebreziabher M;Melikam E;Warth S;Arulogun O;Lackland D;Ogunniyi A;Tiwari H;Kalaria RN;Arnett D;Owolabi MO;SIREN Investigators as Members of the H3Africa Consortium
全世界六分之一的人一生中都会经历中风。虽然与世界其他地区相比，非洲人中风不良后果的负担要高得多，但基因组因素对这种差异的确切影响尚不清楚。尽管对中风基因组学的研究值得注意，但探索美国非洲裔人群中遗传对中风的影响的研究却很少。此外，缺乏非洲人口的基因组学数据。非洲人群广泛的基因组变异为识别与不同种族群体中风因果关系的基因组变异提供了独特的机会。中风调查研究和教育网络 (SIREN) 是非洲人类健康和遗传 (H3Africa) 联盟的组成部分，旨在探索西非和美国非洲血统人群中风的基因组和环境危险因素。在本文中，我们回顾了有关中风基因组学的文献，特别重点关注非洲裔人群。
One in six people worldwide will experience a stroke in his/her lifetime. While people in Africa carry a disproportionately higher burden of poor stroke outcomes, compared to the rest of the world, the exact contribution of genomic factors to this disparity is unknown. Despite noteworthy research into stroke genomics, studies exploring the genetic contribution to stroke among populations of African ancestry in the United States are few. Furthermore, genomics data in populations living in Africa are lacking. The wide genomic variation of African populations offers a unique opportunity to identify genomic variants with causal relationships to stroke across different ethnic groups. The Stroke Investigative Research and Educational Network (SIREN), a component of the Human Health and Heredity in Africa (H3Africa) Consortium, aims to explore genomic and environmental risk factors for stroke in populations of African ancestry in West Africa and the United States. In this article, we review the literature on the genomics of stroke with particular emphasis on populations of African origin.