Synthesis and antitumor-evaluation of 1,3,4-thiadiazole-containing benzisoselenazolone derivatives.
Synthesis and antitumor-evaluation of 1,3,4-thiadiazole-containing benzisoselenazolone derivatives.
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DOI：
10.1016/j.bmcl.2012.03.043
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发表时间：
2012-05
影响因子：
2.7
通讯作者：
Zhenhua Luo;Baoquan Chen;Shuangyan He;Yanping Shi;Yu-Ming Liu;Caiwen Li
中科院分区：
文献类型：
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作者：
Zhenhua Luo;Baoquan Chen;Shuangyan He;Yanping Shi;Yu-Ming Liu;Caiwen Li
以2-氯硒苯甲酰氯和2-氨基-5-取代-1,3,4-噻二唑为原料，缩合制备了一系列新型的含1,3,4-噻二唑类苯并异硒唑酮衍生物。分别对SSMC-7721、MCF-7和A-549细胞进行体外抗增殖活性测定。结果表明，在不同的肿瘤细胞中，部分化合物具有良好的抗增殖活性，具有一定的选择性，具有进一步研究的潜在价值。
A series of novel 1,3,4-thiadiazole-containing benzisoselenazolone derivatives were prepared by the condensation of 2-chloroselenobenzoyl chloride and 2-amino-5-substituted-1,3,4-thiadiazole. Their in vitro antiproliferative activities were evaluated in SSMC-7721, MCF-7 and A-549 cells. The results suggest that, in different tumor cells, some compounds have good antiproliferative activity, certain selectivity and potential value of further research.