The Relationship between Diurnal Variations in Intraocular Pressure Measurements and Central Corneal Thickness and Corneal Hysteresis
The Relationship between Diurnal Variations in Intraocular Pressure Measurements and Central Corneal Thickness and Corneal Hysteresis
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DOI：
10.1167/iovs.08-2955
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发表时间：
2009-09-01
影响因子：
4.4
通讯作者：
Garway-Heath, David F.
中科院分区：
文献类型：
--
作者：
Kotecha, Aachal;Crabb, David P.;Garway-Heath, David F.
目的.目的探讨Goldmann压平眼压计（GAT）和动态轮廓眼压计（DCT）测量的眼压值与角膜特征、中央角膜厚度（CCT）和角膜滞后（CH）的关系。62名未经治疗的正常受试者和患有未经治疗的青光眼的患者的62只眼睛从上午9点开始以2小时的间隔在8小时内用GAT（mm Hg）和DCT（mm Hg）进行IOP测量。CCT（微米）使用非接触式光学低相干反射（OLCR）厚度计测量，CH（mm Hg）使用眼反应分析仪（ORA）测量。在测量期间，通过使用多水平模型评估每个患者的IOP测量值和角膜特征之间的关联。GAT和DCT眼压和CCT在办公时间内变化显著（ANOVA; GAT：F = 19.9，P < 0.001; DCT：F = 4.6，P = 0.001; CCT：F = 16.4; P < 0.001）。CH未观察到显著变化（ANOVA; F = 1.8，P = 0.13）。对CCT、CH和年龄与IOP测量值之间的相互关系进行的多水平建模分析显示，CCT和CH变化均与GAT IOP变化显著相关（GAT IOP/CCT斜率，0.04 mm Hg/mu m; 95%置信区间[CI]，0.02-0.06; GAT IOP/CH斜率，0.20 mm Hg/mm Hg; 95% CI，0.01-0.39）。CCT（而非CH）变化与DCT IOP变化显著相关（DCT IOP/CCT斜率，0.03 mm Hg/mu m; 95% CI，0.00-0.05）。然而，尽管受试者之间CCT和GAT IOP之间的相关性相对一致，但CCT和DCT IOP之间的相关性显示出更大的受试者间变异性。年龄对两种装置测量的IOP的昼夜变化没有影响。办公时间内测量的IOP和角膜特征存在协变。CCT和CH的变化与GAT IOP的变化相关，与DCT IOP的变化不太一致。数据表明，角膜特征的变化解释了在办公时间内使用GAT进行的IOP测量的一小部分变化。（Invest Ophthalmol维斯科学。2009;50：4229-4236）DOI：10.1167/iovs.08-2955
PURPOSE. To examine the relationship between office-hour changes in IOP, measured with the Goldmann applanation tonometer (GAT) and dynamic contour tonometer (DCT), and the corneal characteristics central corneal thickness (CCT) and corneal hysteresis (CH).METHODS. Sixty-two eyes of 62 untreated normal subjects and patients with untreated glaucoma had IOP measurements performed with the GAT (mm Hg) and DCT (mm Hg) over an 8-hour period at 2-hour intervals beginning at 9 AM. CCT (micrometers) was measured using a noncontact optical low-coherence reflectometry (OLCR) pachymeter, and CH (mm Hg) was measured with an ocular response analyzer (ORA). The associations between IOP measurements and corneal characteristics for each patient over the measurement period were assessed by using multilevel modeling.RESULTS. GAT and DCT IOP and CCT changed significantly during office hours (ANOVA; GAT: F = 19.9, P < 0.001; DCT: F = 4.6, P = 0.001; CCT: F = 16.4; P < 0.001). No significant changes were observed in CH (ANOVA; F = 1.8, P = 0.13). Multilevel modeling analysis of the interrelationships between CCT, CH, and age on IOP measurements revealed that both CCT and CH changes were significantly associated with GAT IOP changes (GAT IOP/CCT slope, 0.04 mm Hg/mu m; 95% confidence intervals [CIs], 0.02-0.06; GAT IOP/CH slope, 0.20 mm Hg/mm Hg; 95% CI, 0.01-0.39). CCT, but not CH, changes were significantly associated with DCT IOP changes (DCT IOP/CCT slope, 0.03 mm Hg/mu m; 95% CI, 0.00-0.05). However, although the association between CCT and GAT IOP was relatively uniform between subjects, association between CCT and DCT IOP showed greater intersubject variability. Age had no effect on the diurnal variation of IOP measured with either device.CONCLUSIONS. Measured IOP and corneal characteristics covary during office hours. Changes in CCT and CH are associated with changes in GAT IOP and, less consistently, with DCT IOP. The data suggest that variations in corneal characteristics explain a small proportion of the change in IOP measurements made with the GAT during office hours. (Invest Ophthalmol Vis Sci. 2009;50:4229-4236) DOI: 10.1167/iovs.08-2955