IS AGING AS COMPLEX AS IT WOULD APPEAR - NEW PERSPECTIVES IN AGING RESEARCH
IS AGING AS COMPLEX AS IT WOULD APPEAR - NEW PERSPECTIVES IN AGING RESEARCH
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DOI：
10.1111/j.1749-6632.1992.tb38685.x
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发表时间：
1992-11-21
期刊：
影响因子：
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通讯作者：
FRANCESCHI, C
中科院分区：
文献类型：
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作者：
KIRKWOOD, TBL;FRANCESCHI, C
有多少因素导致了衰老过程？有多少基因决定寿命？随机事件和程序事件哪个更重要？如何区分主要因素和次要因素？细胞是衰老还是仅仅经历终末分化？在衰老过程中，活跃的细胞死亡（凋亡）有多重要？细胞死亡的机制是什么？是否有一个中央老化时钟，例如，通过神经内分泌系统？我们如何研究细胞防御反应网络，以评估它们在衰老中的作用？这些都是本次会议讨论的关于老龄化的一些具有挑战性的问题。在这个结论性的讨论中，我们考虑衰老过程是否真的像它看起来那样复杂，我们研究正在开放的衰老研究的新视角。我们讨论的核心是本次会议所代表的观点，即如果我们要从整体上了解衰老现象，就有必要对衰老的组成过程进行综合研究。'，*
How many factors contribute to the aging process? How many genes determine longevity? Are stochastic or programmed events more important? How do we distinguish primary and secondary factors? Do cells senesce or merely undergo terminal differentiation? How important in aging is active cell death (apoptosis)? What are the mechanisms of cell death? Is there a central aging clock, eg, via the neuroendocrine system? How do we investigate networks of cellular defense reactions to assess their role in aging?These are some of the challenging questions about aging that this conference has addressed. In this concluding discussion we consider if the aging process is really as complex as it would appear, and we examine new perspectives in aging research that are opening out. At the heart of our discussion is the view, represented in this conference, that an integrated study of the component processes of aging is necessary if we are to understand the phenomenon of senescence as a whole.‘,*