Decreased probability of neurotransmitter release underlies striatal long-term depression and postnatal development of corticostriatal synapses
Decreased probability of neurotransmitter release underlies striatal long-term depression and postnatal development of corticostriatal synapses
复制标题
DOI：
10.1073/pnas.94.6.2665
复制
发表时间：
1997-03-18
影响因子：
11.1
通讯作者：
Lovinger, DM
中科院分区：
文献类型：
--
作者：
Choi, S;Lovinger, DM
突触效能的变化对适当的神经回路和大脑信息存储的发展至关重要。我们研究了纹状体谷氨酸能突触长期抑制(LTD)的机制，纹状体是运动表现和认知的重要脑区，也是亨廷顿和帕金森疾病的靶点，纹状体LTD的诱导依赖于突触后去极化和通过L类型通道的钙内流。令人惊讶的是，LTD的维持似乎涉及从突触前终末释放神经递质的概率降低，这表现为与LTD表达密切相关的双脉冲易化和突触反应变异系数的增加。此外，在出生后发育过程中，神经递质释放的表观概率和LTD的大小都随之降低，这与纹状体LTD参与皮质纹状体突触神经递质释放概率的发育性降低的观点一致。纹状体LTD下的突触前改变可能对运动表现和某些形式的学习和记忆也很重要。
Changes in synaptic efficacy are crucial for the development of appropriate neural circuits and brain information storage. We have investigated mechanisms underlying long-term depression (LTD) at glutamatergic synapses in the striatum, a brain region important in motor performance and cognition, and a target for Huntington and Parkinson diseases, Induction of striatal LTD is dependent on postsynaptic depolarization and calcium influx through L-type channels. Surprisingly, LTD maintenance appears to involve a decrease in the probability of neurotransmitter release from presynaptic terminals as evidenced by increases in paired-pulse facilitation and the coefficient of variation of synaptic responses that are tightly associated with LTD expression, Furthermore, both the apparent probability of neurotransmitter release and the magnitude of LTD decrease concomitantly during postnatal development, consistent with the idea that striatal LTD is involved in a developmental decrease in the probability of neurotransmitter release at corticostriatal synapses. The presynaptic changes that under lie striatal LTD may also be important for motor performance and certain forms of learning and memory.