Effect of serotonin and serotonin analogues on passive membrane properties of lateral septal neurons in vitro.
Effect of serotonin and serotonin analogues on passive membrane properties of lateral septal neurons in vitro.
复制标题
血清素和血清素类似物对体外外侧间隔神经元被动膜特性的影响。
DOI：
10.1016/0006-8993(87)90183-1
复制
发表时间：
1987
期刊：
影响因子：
2.9
通讯作者：
Gallagher,JP
中科院分区：
文献类型：
--
作者：
Joëls,M;Shinnick-Gallagher,P;Gallagher,JP
In this study we have tested the effect of serotonin (5-HT) and serotonin-analogues on passive membrane properties of septal neurons in a rat brain slice. Superfusion with 5-HT hyperpolarized the memebrane potential and decreased membrane resistance of lateral septal neurons in a concentration dependent manner. The lowest effective concentration was 1μM while maximal effects were observed with 30 μM. Hyperpolarizing responses to 5-HT persisted in the presence of haloperidol, phentolamine or ritanserin. The 5-HT1aagonist 8-hydroxy-2-[n-dipropylamino]tetralin (8OHDPAT) hyperpolarized lateral septal neurons like 5-HT though the agonist was active at a lower concentration than 5-HT and induced longer-lasting effects. Two other 5-HT1aanalogues, TVX Q 7821 and buspirone, could also mimick the effect of 5-HT. The 5-HT1bagonist 1-(m-trifluoromethylphenyl)piperazine (TFMPP) did not appreciably affect the membrane potential or resistance of septal neurons. The present results are consistent with data from binding studies and suggest that the effect of 5-HT on lateral septal neurons is at least partly mediated through 5-HT1a-like receptors.
