RNA Granules in Germ Cells
RNA Granules in Germ Cells
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DOI：
10.1101/cshperspect.a002774
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发表时间：
2011-12-01
影响因子：
7.2
通讯作者：
Nagamori, Ippei
中科院分区：
文献类型：
--
作者：
Voronina, Ekaterina;Seydoux, Geraldine;Nagamori, Ippei
“生殖颗粒”是生殖系所特有的细胞质无膜细胞器。生殖颗粒与体细胞的P小体和应激颗粒有共同的成分，但也包含生殖细胞发育所特有的蛋白质和RNA。在这篇综述中，我们重点关注在生殖颗粒组装、动态变化和功能方面我们理解的最新进展。一种假说认为，生殖颗粒作为基因表达转录后调控的枢纽发挥作用，这是生殖细胞分化程序的核心功能。
"Germ granules" are cytoplasmic, nonmembrane-bound organelles unique to germline. Germ granules share components with the P bodies and stress granules of somatic cells, but also contain proteins and RNAs uniquely required for germ cell development. In this review, we focus on recent advances in our understanding of germ granule assembly, dynamics, and function. One hypothesis is that germ granules operate as hubs for the post-transcriptional control of gene expression, a function at the core of the germ cell differentiation program.