CEREBELLUM AND MEMORY - AN EXPERIMENTAL-STUDY IN THE RAT USING A PASSIVE-AVOIDANCE CONDITIONING TEST
CEREBELLUM AND MEMORY - AN EXPERIMENTAL-STUDY IN THE RAT USING A PASSIVE-AVOIDANCE CONDITIONING TEST
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DOI：
10.1016/0031-9384(91)90272-p
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发表时间：
1991-03-01
影响因子：
2.9
通讯作者：
CASTON, J
中科院分区：
文献类型：
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作者：
GUILLAUMIN, S;DAHHAOUI, M;CASTON, J
成年DA/HAN品系大鼠进行一项单次被动回避条件反射实验，该实验将黑暗与伤害性刺激相关联。在一次试验的初始体验后7天或14天，他们再次接受测试，以了解他们是否忘记了它。将动物分为小脑切除术前条件组（COC组）和非条件组（NOC组），以及完整组（C组）和假手术组（SO组）两个对照组。每组分为2个亚组，分别在初始条件反射后第7天和第14天进行检索测试。结果表明，C、SO和NOC大鼠在第7天和第14天的保留率相似。在初始体验和小脑切除术后7天，COC大鼠的保留率为零，而在小脑切除术后14天进行测试时，这些动物的评分要好得多，明显高于病变后7天。结果表明，小脑参与了记忆痕迹的巩固过程，但不是记忆储存的场所。
Adult DA/HAN strain rats were submitted to a one-trial passive avoidance conditioning procedure consisting in associating darkness with a nociceptive stimulus. Seven or fourteen days after the one-trial initial experience, they were tested again in order to know whether they had forgotten it or not. The animals were divided into two experimental groups, the rats being either conditioned (COC group) or not (NOC group) before cerebellectomy, and two control groups, the animals being either intact (C group) or sham-operated (SO group). Each group was divided into two subgroups, one being given the retrieval test 7 days and the other 14 days after the initial conditioning. The results show that retention in C, SO and NOC rats was similar whether the animals were tested 7 days or 14 days after the initial one-trial conditioning. Seven days after their initial experience and the cerebellectomy, the retention in COC rats was null while when they were tested 14 days after cerebellar removal these animals had much better scores, significantly higher than 7 days after the lesion. It is concluded that the cerebellum is involved in the consolidation processes of the memory trace but is not the site of memory storage.