Cellular complexity of the bone marrow hematopoietic stem cell niche.
Cellular complexity of the bone marrow hematopoietic stem cell niche.
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DOI：
10.1007/s00223-013-9805-8
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发表时间：
2014-01
影响因子：
4.2
通讯作者：
Link, Daniel C.
中科院分区：
文献类型：
--
作者：
Calvi, Laura M.;Link, Daniel C.
骨骼是成年陆生脊椎动物的主要造血点。造血系统的功能是维持所有循环血细胞的动态平衡水平，包括髓系细胞、淋巴样细胞、红细胞和血小板。这一行动需要每天生产超过5000亿个血细胞。这些细胞中的绝大多数是在骨髓中合成的，在那里它们来自有限数量的造血干细胞(HSCs)，这些干细胞具有多潜能并能够广泛自我更新。造血干细胞的这些属性在骨髓移植中得到了最好的证明，在骨髓移植中，即使是一个单独的造血干细胞也可以重新填充整个造血系统。因此，造血干细胞是能够多系再繁殖的成体干细胞，在细胞命运选择之间保持平衡，包括静止、自我更新、分化和凋亡。虽然HSC的命运选择在一定程度上是由细胞自主过程的多重随机波动决定的，但根据生态位假说，来自微环境的信号也可能决定干细胞的命运。虽然长期以来一直认为骨髓中的信号可以调节造血细胞，但直到最近十年，流式细胞术和遗传模型的进步才使人们能够更深入地了解造血干细胞的微环境调节。在这篇综述中，我们将重点介绍HSC利基的细胞调节组件。
The skeleton serves as the principal site for hematopoiesis in adult terrestrial vertebrates. The function of the hematopoietic system is to maintain homeostatic levels of all circulating blood cells, including myeloid cells, lymphoid cells, red blood cells, and platelets. This action requires the daily production of more than 500 billion blood cells every day. The vast majority of these cells are synthesized in the bone marrow, where they arise from a limited number of hematopoietic stem cells (HSCs) that are multipotent and capable of extensive self-renewal. These attributes of HSCs are best demonstrated by marrow transplantation, where even a single HSC can repopulate the entire hematopoietic system. HSCs are therefore adult stem cells capable of multilineage repopulation, poised between cell fate choices, which include quiescence, self-renewal, differentiation and apoptosis. While HSC fate choices are in part determined by multiple stochastic fluctuations of cell autonomous processes, according to the niche hypothesis, signals from the microenvironment are also likely to determine stem cell fate. While it had long been postulated that signals within the bone marrow could provide regulation of hematopoietic cells, it is only in the past decade that advances in flow cytometry and genetic models have allowed for a deeper understanding of microenvironmental regulation of HSCs. In this review, we will highlight the cellular regulatory components of the HSC niche.
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影响因子：
23.9
作者：
Butler JM;Nolan DJ;Vertes EL;Varnum-Finney B;Kobayashi H;Hooper AT;Seandel M;Shido K;White IA;Kobayashi M;Witte L;May C;Shawber C;Kimura Y;Kitajewski J;Rosenwaks Z;Bernstein ID;Rafii S
通讯作者：
Rafii S
影响因子：
64.8
作者：
Chen, Michael J.;Yokomizo, Tomomasa;Zeigler, Brandon M.;Dzierzak, Elaine;Speck, Nancy A.
通讯作者：
Speck, Nancy A.
影响因子：
82.9
作者：
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影响因子：
20.3
作者：
Chitteti, Brahmananda R.;Cheng, Ying-Hua;Srour, Edward F.
通讯作者：
Srour, Edward F.
影响因子：
4.3
作者：
Ballen, Karen K.;Shpall, Elizabeth J.;Spitzer, Thomas R.
通讯作者：
Spitzer, Thomas R.