The incidence of syphilis, HIV and HCV and associated factors in a cohort of men who have sex with men in Nanjing, China
The incidence of syphilis, HIV and HCV and associated factors in a cohort of men who have sex with men in Nanjing, China
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DOI：
10.1136/sti.2010.042903
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发表时间：
2011-04-01
影响因子：
3.6
通讯作者：
Lau, Joseph T. F.
中科院分区：
文献类型：
--
作者：
Hao, Chun;Yan, Hongjing;Lau, Joseph T. F.
目的了解南京市男男性行为人群（MSM）梅毒、HIV、HCV感染情况及梅毒血清转换相关因素。那些在基线时梅毒，HIV和HCV血清阴性的人被邀请在第6个月重新检测。结果416名受试者中，基线时HIV、梅毒和HCV阴性者348名，其中250名（71.84%）在6个月时返回进行复检。这250例受试者中有9例血清转化为梅毒阳性（发生率=7.58/100人-年（PY）; 95% CI 2.63 - 12.53/100 PY），5例血清转化为HIV阳性（发生率=4.17/100 PY; 95% CI=0.52 - 7.83/100 PY）。多因素分析显示，目前单身婚姻状况（RR=0.32，95%CI 0.16 ~ 0.65，p <0.001）和目前未婚婚姻状况（RR= 2.68，95%CI 1.28 ~ 5.61，p <0.001）是梅毒血清转换的4个显著预测因素（RR=0.32，95%CI 0.16 ~ 0.65，p <0.001），而目前未婚婚姻状况（RR=2.68，95%CI 1.28 ~ 5.61，p <0.001）是梅毒血清转换的4个显著预测因素（RR=0.32，95%CI 0.16 ~ 0.65，p <0.001）。
Objective This study investigated the incidence of syphilis, HIV and hepatitis C virus (HCV), as well as factors associated with syphilis seroconversion among men who have sex with men (MSM) in Nanjing, China.Methods A cohort of MSM was recruited by respondent-driven sampling methods. Those who were syphilis-, HIV- and HCV-seronegative at the baseline were invited to be retested at month 6. A Poisson regression analysis was performed.Results Of the 416 participants in the study, 348 participants were HIV-, syphilis-and HCV-negative at the baseline, 250 (71.84%) of whom returned for retesting at month 6. Nine of these 250 participants had seroconverted to syphilis-positive (incidence=7.58 per 100 person-years (PY); 95% CI 2.63 to 12.53 per 100 PY), and five had seroconverted to HIV-positive (incidence=4.17 per 100 PY; 95% CI=0.52 to 7.83 per 100 PY). No HIV and syphilis coinfection and no HCV seroconversion were found. Multivariate analysis identified four statistically significant factors predicting syphilis seroconversion, including currently single marital status (RR=0.32, 95% CI 0.16 to 0.65, pUS$300 (RR=2.68, 95% CI 1.28 to 5.61, p