Disturbed macro-connectivity in schizophrenia linked to oligodendrocyte dysfunction: from structural findings to molecules.
Disturbed macro-connectivity in schizophrenia linked to oligodendrocyte dysfunction: from structural findings to molecules.
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DOI：
10.1038/npjschz.2015.34
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发表时间：
2015
影响因子：
5.4
通讯作者：
Martins-de-Souza D
中科院分区：
文献类型：
--
作者：
Cassoli JS;Guest PC;Malchow B;Schmitt A;Falkai P;Martins-de-Souza D
精神分裂症是一种具有多因素特征的严重精神障碍。许多研究结果表明，精神分裂症患者的突触连接被破坏，新出现的证据表明，这是由功能障碍的少突胶质细胞造成的，少突胶质细胞负责在白色物质中形成髓鞘轴突以促进神经元传导。其确切原因尚不清楚，尽管最近对精神分裂症患者的成像和分子分析研究已经确定了连接多个大脑区域的白色物质束的变化，这些变化影响了参与髓鞘形成过程的蛋白质信号网络。对精神分裂症中少突胶质细胞功能障碍的进一步了解可能会导致识别这种毁灭性疾病的新药物靶点。
Schizophrenia is a severe psychiatric disorder with multi-factorial characteristics. A number of findings have shown disrupted synaptic connectivity in schizophrenia patients and emerging evidence suggests that this results from dysfunctional oligodendrocytes, the cells responsible for myelinating axons in white matter to promote neuronal conduction. The exact cause of this is not known, although recent imaging and molecular profiling studies of schizophrenia patients have identified changes in white matter tracts connecting multiple brain regions with effects on protein signaling networks involved in the myelination process. Further understanding of oligodendrocyte dysfunction in schizophrenia could lead to identification of novel drug targets for this devastating disease.