Renal BOLD-MRI does not reflect renal function in chronic kidney disease
Renal BOLD-MRI does not reflect renal function in chronic kidney disease
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DOI：
10.1038/ki.2011.455
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发表时间：
2012-04-01
影响因子：
19.6
通讯作者：
Attenberger, Ulrike I.
中科院分区：
文献类型：
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作者：
Michaely, Henrik J.;Metzger, Linda;Attenberger, Ulrike I.
肾血氧水平依赖性磁共振成像（BOLD-MRI）是一种无创快速评价肾功能的技术。在这里，我们评估了肾功能对皮质和髓质舒张率（R2*）的影响，为进一步使用肾脏BOLD-MRI提供基线数据。在400例计划进行腹部成像的患者中评价了该参数，这些患者采用12个回波时间的多回波梯度回波序列进行了横向血氧水平依赖性测量。生成相位相干性损失（T2*）图，其中选择感兴趣的肾脏区域以区分髓质和皮质，R2* 等于1/T2*。个体R2* 值依次与342例患者的eGFR（280例具有可用血清肌酐测量值的患者的MDRD公式）、年龄和性别相关，分别用于1.5和3.0T场强扫描。在两种场强下，使用KDOQI系统确定的患者性别、年龄、eGFR或慢性肾脏疾病的不同阶段之间的皮质和髓质的R2* 无显著差异。因此，非特异性患者人群的BOLD-MRI无法区分不同阶段的慢性肾脏疾病患者。Kidney International（2012）81，684-689; doi：10.1038/ki.2011.455; 2012年1月11日在线发表
Renal blood oxygen level-dependent magnetic resonance imaging (BOLD-MRI) is a noninvasive fast technique to characterize renal function. Here we evaluated the impact of renal function on the relaxation rate (R2*) in the cortex and medulla to provide baseline data for further use of renal BOLD-MRI. This parameter was evaluated in 400 patients scheduled for abdominal imaging who underwent transversal blood oxygen level-dependent measurements with a multi-echo gradient-echo sequence with 12 echo times. The loss of phase coherence (T2*) maps were generated in which kidney regions of interest were selected to differentiate the medulla and cortex, and R2* was equated to 1/T2*. Individual R2* values were, in turn, correlated to the eGFR (MDRD formula of 280 patients with available serum creatinine measurements), age, and gender each for 1.5 and 3.0T field-strength scans of 342 patients. At both the field strengths, no significant differences in R2* of the cortex and medulla were found between patient gender, age, eGFR, or between different stages of chronic kidney disease determined using the KDOQI system. Thus, BOLD-MRI of a non-specific patient population failed to discriminate between the patients with various stages of chronic kidney disease. Kidney International (2012) 81, 684-689; doi:10.1038/ki.2011.455; published online 11 January 2012