C-reactive protein is related to impaired oxygenation in patients with acute aortic dissection
C-reactive protein is related to impaired oxygenation in patients with acute aortic dissection
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DOI：
10.1536/ihj.46.795
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发表时间：
2005-09-01
影响因子：
1.5
通讯作者：
Mochizuki, S
中科院分区：
文献类型：
--
作者：
Komukai, K;Shibata, T;Mochizuki, S
急性主动脉夹层患者有时会出现氧合受损，但其机制尚未得到充分研究。我们假设氧合受损与主动脉夹层继发炎症有关。对接受保守治疗14 d的急性主动脉夹层患者进行回顾性检查。接受过手术或在 14 天内死亡的患者被排除，在此期间有肺炎或肺充血证据的患者也被排除。 26 名患者被分为氧合保留组（最低氧合指数 >= 200，n = 13）和氧合受损组（最低氧合指数 < 200，n = 13）。比较两组患者血清最大C反应蛋白（max CRP）及其他因素（年龄、年龄、高血压、糖尿病、吸烟、高脂血症、Stanford型、假腔血栓、胸腔积液、肺不张、静脉使用血管扩张剂）。通过单/多重 Logistic 回归分析计算，最大 CRP 是氧合受损的唯一预测因子。氧合受损组的最大 CRP (20.1 +/- 2.1 mg/dL) 显着高于氧合保留组 (10.5 +/- 1.4 mg/dL，P < 0.05)。这些结果表明，氧合受损与炎症有关，炎症是急性主动脉夹层继发性的。
Impaired oxygenation sometimes occurs in patients with acute aortic dissection, however, the mechanism has not been fully investigated. We hypothesized that impaired oxygenation is related to inflammation secondary due to aortic dissection. Patients with acute aortic dissection who had received 14 days of conservative treatment were retrospectively examined. Patients who had undergone surgery or died within 14 days were excluded Patients who had evidence of having pneumonia or pulmonary congestion during this period were also excluded. Twenty-six patients were divided into a preserved oxygenation group (minimum oxygenation index >= 200, n = 13) and an impaired oxygenation group (minimum oxygenation index < 200, n = 13). Maximum serum C-reactive protein (max CRP) and other factors (age, aender, hypertension, diabetes mellitus, smoking, hyperlipidemia, Stanford type, thrornbosed false lumen, pleural effusion, atelectasiS, use of intravenous vasodilators) for the two groups were compared. Max CRP was the only predictor for impaired oxygenation as calculated by single/multiple logistic regression analysis. Max CRP was significantly higher in the impaired oxygenation group (20.1 +/- 2.1 mg/dL) than in the preserved oxygenation group (10.5 +/- 1.4 mg/dL, P < 0.05). These results Sliggest that impaired oxygenation is related to inflammation, which is secondary due to acute aortic dissection.