Optical coherence tomography of laryngeal cancer
Optical coherence tomography of laryngeal cancer
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DOI：
10.1097/01.mlg.0000217539.27432.5a
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发表时间：
2006-07-01
期刊：
影响因子：
2.6
通讯作者：
Wong, Brian J. F.
中科院分区：
文献类型：
--
作者：
Armstrong, William B.;Ridgway, James M.;Wong, Brian J. F.
目的：光学相干断层扫描（OCT）是一种高分辨率光学成像技术，它以类似于超声的方式使用光产生活组织的横截面图像。这项前瞻性研究评价了OCT识别喉癌特征和测量基底膜、组织显微结构和肿瘤边缘移行区变化的能力。材料和方法。133例患者在头颈部外科内窥镜检查期间接受了OCT检查。22例喉癌患者或有喉癌病史的患者使用光纤OCT系统进行成像。肿瘤和邻近的移行区沿着与未涉及的亚位点成像。OCT图像与组织病理学相关。结果：22例患者共进行了26次OCT检查。基底膜破坏见于18例受试者，所有受试者的组织学均显示典型的癌症特征。在肿瘤周围也经常观察到向未受累上皮的过渡区。在6项研究中，良性或癌前病变的组织学证实。在3个薄的浅表病变中，观察到完整的基底膜。基底膜不能确定在其他三个庞大的外生性，癌前病变，主要是因为增加了浅表信号的反向散射观察病理组织。结论. OCT可以清楚地识别喉癌的基底膜破坏，并可以识别癌边缘的过渡区。在巨大的外生性病变中，OCT信号可能穿透得不够深，无法显示基底膜，但对于许多需要排除癌症的可疑病变，OCT显示出辅助诊断评估的潜力。
Objectives: Optical coherence tomography (OCT) is a high-resolution optical imaging technique that produces cross-sectional images of living tissues using light in a manner similar to ultrasound. This prospective study evaluated the ability of OCT to identify the characteristics of laryngeal cancer and measure changes in the basement membrane, tissue microstructure, and the transition zone at the edge of tumors. Materials and Methods. One hundred thirty-three patients underwent OCT examination during surgical endoscopy of the head and neck. Twenty-two patients with laryngeal cancer or a history of laryngeal cancer were imaged with a fiberoptic OCT system. Tumor and adjacent transition zones were imaged along with uninvolved subsites. OCT images were correlated with histopathology. Results: Twenty-six OCT examinations were performed in 22 patients. Basement membrane disruption was seen in 18 subjects, all of whom had histology showing classic features of cancer. A transition zone to uninvolved epithelium at the tumor periphery was also often observed. In six studies, benign or premalignant processes were histologically confirmed. In three thin, superficial lesions, an intact basement membrane was observed. The basement membrane could not be identified in three other bulky exophytic, premalignant lesions, primarily because of increased superficial signal backscattering observed in pathologic tissues. Conclusions. OCT clearly identifies basement membrane violation from laryngeal cancer and can identify transition zones at the cancer margin. In bulky exophytic lesions, OCT signal may not penetrate deeply enough to show the basement membrane, but for many suspicious lesions that require exclusion of cancer, OCT shows potential for assisting in diagnostic assessment.