Ubiquitination: RING for destruction?

Ubiquitination: RING for destruction?
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DOI:
10.1016/s0960-9822(00)00287-6
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发表时间:
2000-01-27
期刊:
影响因子:
9.2
通讯作者:
Freemont, PS
Freemont, PS
中科院分区:
生物学1区
文献类型:
--
作者:
Freemont, PS

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泛素化以蛋白质降解为目标,是细胞蛋白质功能的有效调节剂。最近的结果表明环指结构域参与了特定的泛素化事件;所有 RING 蛋白都可能充当 E3 泛素蛋白连接酶,对多种生物领域产生影响。
Ubiquitination targets proteins for degradation and is a potent regulator of cellular protein function. Recent results implicate the RING finger domain in specific ubiquitination events; it is possible that all RING proteins act as E3 ubiquitin protein ligases, with implications for a variety of biological areas.