A case of Bowen's disease and small-cell lung carcinoma: long-term consequences of chronic arsenic exposure in Chinese traditional medicine.
A case of Bowen's disease and small-cell lung carcinoma: long-term consequences of chronic arsenic exposure in Chinese traditional medicine.
复制标题
鲍文病和小细胞肺癌的病例：中国传统医学中慢性砷暴露的长期后果。
DOI：
10.1289/ehp.7200
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发表时间：
2005-02
影响因子：
10.4
通讯作者：
Bebb, Gwyn
中科院分区：
文献类型：
--
作者：
Lee, Linda;Bebb, Gwyn
慢性砷中毒主要通过无意中摄入受污染的水和食物或职业接触发生，但也可通过药物摄入发生。本病例为53岁终身不吸烟慢性哮喘患者，儿童期服用含砷中药治疗10年。该患者被诊断为鲍恩氏病，并在接触砷10年和47年后分别发展为广泛期肺小细胞癌。虽然砷作为一种药物已有很长的历史，但它是一种致癌物质，与包括皮肤和肺部在内的许多恶性肿瘤有关。它更常与非小细胞肺癌相关，但在没有其他化学物质或职业接触的情况下，与鲍恩氏病的时间关联强烈表明，砷在本例小细胞肺癌中起着因果作用。有砷诱发的鲍文氏病的个体应考虑进行更积极的长期并发症筛查，特别是后续恶性肿瘤的发展。
Chronic arsenic toxicity occurs primarily through inadvertent ingestion of contaminated water and food or occupational exposure, but it can also occur through medicinal ingestion. This case features a 53-year-old lifetime nonsmoker with chronic asthma treated for 10 years in childhood with Chinese traditional medicine containing arsenic. The patient was diagnosed with Bowen’s disease and developed extensive-stage small-cell carcinoma of the lung 10 years and 47 years, respectively, after the onset of arsenic exposure. Although it has a long history as a medicinal agent, arsenic is a carcinogen associated with many malignancies including those of skin and lung. It is more commonly associated with non–small-cell lung cancer, but the temporal association with Bowen’s disease in the absence of other chemical or occupational exposure strongly points to a causal role for arsenic in this case of small-cell lung cancer. Individuals with documented arsenic-induced Bowen’s disease should be considered for more aggressive screening for long-term complications, especially the development of subsequent malignancies.