Changes Depression- and Anxiety- like Behaviors following Selective Breeding for Cocaine Reinforcement.
Changes Depression- and Anxiety- like Behaviors following Selective Breeding for Cocaine Reinforcement.
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改变可卡因强化选择性育种后的抑郁和焦虑样行为。
DOI：
10.1016/j.psychres.2020.113637
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发表时间：
2021
影响因子：
11.3
通讯作者：
Grasing,Kenneth
中科院分区：
文献类型：
--
作者：
Grasing,MichaelJ;Xu,Haiyang;Idowu,JessicaY;Grasing,Kenneth
LS 和 HS 是为改变可卡因自我给药而选择性培育的大鼠品系。考虑到心理健康在物质使用中的重要性，通过强迫游泳和探索正号迷宫，对这些线进行了假定的抑郁和焦虑样行为的评估。我们发现 LS 雄性的挣扎次数增加，LS 雌性的攀爬次数增加，HS 雄性的游泳次数增加；对 HS 菌株的不动性具有双相效应。 HS 大鼠进入十字迷宫的次数较少，在十字迷宫的开放臂中花费的时间也较少，这与更大的焦虑样行为一致，这可能有助于增强药物服用。
The LS and HS are rat lines selectively bred for altered cocaine self-administration. Given the importance of mental health in substance use, these lines were evaluated for putative depression- and anxiety- like behaviors through forced swimming and exploration of a plus maze. We found increases of struggling in LS males, climbing in LS females, and swimming in HS males; with biphasic effects on immobility in the HS strain. HS rats had fewer entries into and less time spent in open arms of the plus maze, consistent with greater anxiety-like behavior, which may contribute to enhanced drug taking.