Immune response in ovarian cancer: how is the immune system involved in prognosis and therapy: potential for treatment utilization.
Immune response in ovarian cancer: how is the immune system involved in prognosis and therapy: potential for treatment utilization.
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DOI：
10.1155/2010/791603
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发表时间：
2010
影响因子：
--
通讯作者：
Bamias A
中科院分区：
文献类型：
--
作者：
Gavalas NG;Karadimou A;Dimopoulos MA;Bamias A
卵巢癌是女性癌症相关死亡的主要原因之一。对疾病的抵抗发生在超过70%的病例中，即使在用化疗剂如紫杉醇和铂类药物治疗后。免疫系统越来越成为密集研究的目标，以研究宿主对卵巢癌的免疫反应。T细胞群，包括NK T细胞和T淋巴细胞，以及细胞因子已与疾病结果相关，表明它们的临床意义增加，分别与预后相关和作为疾病进展的标志物。利用免疫系统的能力以诱导抗肿瘤反应仍然是一个重大挑战。本文探讨了我们对卵巢癌免疫反应发展机制的理解的最新进展，以及其预后意义和临床研究中的现有经验。
Ovarian cancer is one of the leading causes of cancer-related death among women. Resistance to the disease occurs in more than 70% of the cases even after treated with chemotherapy agents such as paclitaxel- and platinum-based agents. The immune system is increasingly becoming a target for intense research in order to study the host's immune response against ovarian cancer. T cell populations, including NK T cells and Tregs, and cytokines have been associated with disease outcome, indicating their increasing clinical significance, having been associated with prognosis and as markers of disease progress, respectively. Harnessing the immune system capacity in order to induce antitumor response remains a major challenge. This paper examines the recent developments in our understanding of the mechanisms of development of the immune response in ovarian cancer as well as its prognostic significance and the existing experience in clinical studies.
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DOI：
10.1111/j.1600-0897.2005.00330.x
发表时间：
2005-12-01
影响因子：
3.6
作者：
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影响因子：
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影响因子：
45.3
作者：
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