Allergic Contact Dermatitis
Allergic Contact Dermatitis
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DOI：
10.1016/j.iac.2016.08.014
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发表时间：
2017-02-01
影响因子：
2.6
通讯作者：
Navarini, Alexander A.
中科院分区：
文献类型：
--
作者：
Kostner, Lisa;Anzengruber, Florian;Navarini, Alexander A.
过敏性接触性皮炎 (ACD) 是一种常见的皮肤病，由 T 细胞介导的对通常无害的过敏原的免疫反应引起。 ACD 可能会产生严重的医疗和社会经济后果。 ACD 和刺激性接触性皮炎常常同时发生。详细的病史和临床检查至关重要，可指导斑贴试验，这是诊断 ACD 的金标准。皮肤中持续存在的 T 细胞克隆可以解释 ACD 即使在多年避免过敏原后仍会复发的趋势。 ACD 的传统治疗方法是局部类固醇、钙调神经磷酸酶抑制剂、光疗、类维生素A（包括最近的阿利维A酸）和免疫抑制剂。缺乏靶向治疗。
Allergic contact dermatitis (ACD) is a common skin disease caused by a T cell mediated immune reaction to usually innocuous allergens. ACD can have grave medical and socioeconomic consequences. ACD and irritant contact dermatitis often occur together. A detailed history and clinical examination are crucial and guide patch testing, which is the gold standard to diagnose ACD. T-cell clones persisting in the skin may explain the tendency of ACD to relapse even after years of allergen avoidance. Traditional treatments for ACD are topical steroids, calcineurin inhibitors, phototherapy, retinoids (including the recent alitretinoin), and immunosuppressants. Targeted therapies are lacking.