Immune Function in Dairy Cows Related to Energy Balance and Metabolic Status in Early Lactation
Immune Function in Dairy Cows Related to Energy Balance and Metabolic Status in Early Lactation
复制标题
奶牛的免疫功能与泌乳早期能量平衡和代谢状态相关
DOI：
--
复制
发表时间：
1989
影响因子：
2.1
通讯作者：
Refsdal Ao
中科院分区：
文献类型：
--
作者：
Erik Ropstad;Larsen Hj;Refsdal Ao
连续两年进行了两次饲养实验，每次实验使用 28 头挪威红牛（NRF）奶牛。将奶牛随机分为 4 组，从产犊前 1 个月到产犊后 12 周接受不同的饲喂方案。实验设计针对精料的蛋白质含量（17.5% 可消化粗蛋白 (DCP) 与 12.5% DCP）和精料限量（产犊后的标准限量与不标准限量）进行阶乘 (2×2)。青贮饲料随意提供。在预期产犊前 4 周以及产犊后 2、4 和 8 周收集样本，用于评估血清免疫球蛋白-G、白细胞和淋巴细胞对促细胞分裂素植物血凝素、刀豆球蛋白 A 和美洲商陆促细胞分裂剂的反应。在产犊时以及产犊后 2、4 和 8 周评估了乳汁免疫球蛋白-G 的水平。在估计的能量平衡和淋巴细胞对有丝分裂原的反应之间发现了显着的正相关关系。几乎没有证据表明免疫参数和代谢状态的血浆指标之间存在显着关系。从产犊到产后8周期间，淋巴细胞对植物血凝素的反应和血清免疫球蛋白-G水平增加，而乳汁免疫球蛋白-G水平下降。乳汁体细胞计数的增加与淋巴细胞对有丝分裂原的反应显着降低有关。
Two feeding experiments were carried out in 2 successive years with 28 cows of the Norwegian Red Cattle (NRF) in each experiment. The cows were randomly distributed into 4 groups and subjected to different feeding regimens from 1 month prior to calving until 12 weeks after calving. The experimental design was factorial (2×2) with respect to protein content of the concentrate (17.5 % digestible crude protein (DCP) v.s. 12.5 % DCP) and concentrate allowances (standard v.s. substandard allowances after calving). Silage was offered ad libitum. Samples for estimation of serum immunoglobulin-G, white blood cells and lymphocyte responses to the mitogens phytohemagglutinin, concanavalin A and pokeweed mitogen were collected 4 weeks prior to expected calving, and 2, 4 and 8 weeks after calving. The levels of milk immunoglobulin-G were estimated at calving and 2, 4 and 8 weeks after calving. A significant positive relationship was found between the estimated energy balance and the lymphocyte response to mitogens. Little evidence was found for the existence of a significant relationsip between the immunologic parameters and plasma indicators of metabolic status. The lymphocyte response to phytohemagglutinin and levels of serum immunoglobulin-G increased, while levels of milk immunoglobulin-G decreased during the period from calving to 8 weeks after calving. Increased milk somatic cell counts were associated with a significant decrease in the lymphocyte responses to mitogens.