Fatty acid transport across the cell membrane: Regulation by fatty acid transporters
Fatty acid transport across the cell membrane: Regulation by fatty acid transporters
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DOI：
10.1016/j.plefa.2010.02.029
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发表时间：
2010-04-01
影响因子：
3
通讯作者：
Glatz, Jan F. C.
中科院分区：
文献类型：
--
作者：
Schwenk, Robert W.;Holloway, Graham P.;Glatz, Jan F. C.
长期以来，长链脂肪酸跨细胞膜的运输一直被认为是通过被动扩散发生的。然而，近年来人们的认识发生了根本性转变，现在普遍认识到脂肪酸通过蛋白质介导的机制穿过细胞膜。膜相关脂肪酸结合蛋白（“脂肪酸转运蛋白”）不仅促进而且调节细胞脂肪酸的摄取，例如通过它们可诱导的快速（和可逆）易位从细胞内储存池到细胞膜。已鉴定出许多脂肪酸转运蛋白，包括 CD36、质膜相关脂肪酸结合蛋白 (FABP) 和脂肪酸转运蛋白家族 (FATP1-6)。脂肪酸转运蛋白还与代谢疾病有关，例如胰岛素抵抗和 2 型糖尿病。在本报告中，我们简要回顾了目前对跨膜脂肪酸转运机制的理解，以及脂肪酸转运蛋白在健康心脏和骨骼肌以及胰岛素抵抗/2 型糖尿病中的功能。脂肪酸转运蛋白有望成为纠正体内脂质流动和恢复代谢稳态的未来目标。 (C) 2010 Elsevier Ltd. 保留所有权利。
Transport of long-chain fatty acids across the cell membrane has long been thought to occur by passive diffusion. However, in recent years there has been a fundamental shift in understanding, and it is now generally recognized that fatty acids cross the cell membrane via a protein-mediated mechanism. Membrane-associated fatty acid-binding proteins ('fatty acid transporters') not only facilitate but also regulate cellular fatty acid uptake, for instance through their inducible rapid (and reversible) translocation from intracellular storage pools to the cell membrane. A number of fatty acid transporters have been identified, including CD36, plasma membrane-associated fatty acid-binding protein (FABP), and a family of fatty acid transport proteins (FATP1-6). Fatty acid transporters are also implicated in metabolic disease, such as insulin resistance and type-2 diabetes. In this report we briefly review current understanding of the mechanism of transmembrane fatty acid transport, and the function of fatty acid transporters in healthy cardiac and skeletal muscle, and in insulin resistance/type-2 diabetes. Fatty acid transporters hold promise as a future target to rectify lipid fluxes in the body and regain metabolic homeostasis. (C) 2010 Elsevier Ltd. All rights reserved.