Gadolinium deposition in the brain: summary of evidence and recommendations
Gadolinium deposition in the brain: summary of evidence and recommendations
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DOI：
10.1016/s1474-4422(17)30158-8
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发表时间：
2017-07-01
期刊：
影响因子：
48
通讯作者：
Reeder, Scott B.
中科院分区：
文献类型：
--
作者：
Gulani, Vikas;Calamante, Fernando;Reeder, Scott B.
新出现的证据表明，脑深部核团的MRI信号变化与重复使用钆基造影剂有关。钆沉积物已被证实存在于脑组织中，最明显的是在齿状核和苍白球中。尽管一些线性造影剂似乎比一些大环造影剂引起更大的MRI信号变化，但在大环造影剂中也观察到钆沉积。然而，钆沉积的程度因试剂而异。此外，脑中残留钆的临床意义（如果有的话）仍然未知。在人类或动物中没有数据显示脑中钆沉积引起的不良临床影响。我们代表国际医学磁共振学会，提出钆基造影剂的临床和研究使用的建议。这些建议可能会随着新证据的出现而演变。
Emerging evidence has linked MRI signal changes in deep nuclei of the brain with repeated administration of gadolinium-based contrast agents. Gadolinium deposits have been confirmed in brain tissue, most notably in the dentate nuclei and globus pallidus. Although some linear contrast agents appear to cause greater MRI signal changes than some macrocyclic agents, deposition of gadolinium has also been observed with macrocyclic agents. However, the extent of gadolinium deposition varies between agents. Furthermore, the clinical significance of the retained gadolinium in the brain, if any, remains unknown. No data are available in human beings or animals to show adverse clinical effects due to the gadolinium deposition in the brain. On behalf of the International Society for Magnetic Resonance in Medicine, we present recommendations for the clinical and research use of gadolinium-based contrast agents. These recommendations might evolve as new evidence becomes available.