Influence of rhBMP-2 on bone formation and osseointegration in different implant systems after sinus-floor elevation. An in vivo study on sheep
Influence of rhBMP-2 on bone formation and osseointegration in different implant systems after sinus-floor elevation. An in vivo study on sheep
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DOI：
10.1016/j.jcms.2010.02.010
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发表时间：
2010-12-01
影响因子：
3.1
通讯作者：
Sauerbier, Sebastian
中科院分区：
文献类型：
--
作者：
Gutwald, Ralf;Haberstroh, Jorg;Sauerbier, Sebastian
背景一些研究已经报道了某些骨形态发生蛋白（BMP）对骨生成具有积极作用。尽管一些研究者已经研究了人重组BMP（rhBMP-2）在绵羊鼻窦提升中的作用，但这些研究都没有观察到在鼻窦提升时植入物的放置。以及如果rhBMP-2用于鼻窦提升手术中，植入物的定位对骨形成的影响。目的本研究的目的是比较在poly-D上使用rhBMP-2的鼻窦提升，L-乳酸-羟基乙酸明胶（PLPG）海绵窦填充术与自体骨盆松质骨在上颌窦中的不同牙科种植体的放置材料和方法9成年雌性绵羊一侧行双侧窦底抬高术（试验组）在PLPG-海绵上用rhBMP-2进行窦提升，而对侧作为对照，使用来自髂嵴的松质骨。（Branemark（R），31（R）和Straumann（R））在6周和12周时处死动物，组织学和组织形态计量学评价，在此期间评价骨-种植体接触（BIC）和骨密度（BD）。结论rhBMP-2与PLPG-2联合应用，可有效地修复骨缺损，且与PLPG-2联合应用，可提高骨缺损修复的成功率。与自体骨相比，海绵增加了增强鼻窦中的BIC和BD。不同的植入物系统和植入物位置对BIC或BD没有影响（C）2010欧洲颅颌面外科协会
Background Several studies have reported certain bone morphogenic proteins (BMPs) to have positive effects on bone generation Although some investigators have studied the effects of human recombinant BMP (rhBMP-2) in sinus augmentation in sheep, none of these studies looked at the placement of implants at the time of sinus augmentation Furthermore, no literature could be found to report on the impact that different implant systems, as well as the positioning of the implants had on bone formation if rhBMP-2 was utilized in sinus-lift procedures Purpose The aim of this study was to compare sinus augmentation with rhBMP-2 on a poly-D, L-lactic-co-glycolic acid gelatine (PLPG) sponge with sinus augmentation with autologous pelvic cancellous bone in the maxillary sinus during the placement of different dental Implants Materials and methods Nine adult female sheep were submitted to bilateral sinus-floor elevation In one side (test group) the sinus lift was performed with rhBMP-2 on a PLPG-sponge, while the contralateral side served as the control by using cancellous bone from the iliac crest Three different implants (Branemark (R), 31 (R) and Straumann (R)) were inserted either simultaneously with the sinus augmentation or as a two staged procedure 6 weeks later The animals were sacrificed at 6 and 12 weeks for histological and histomorphometrical evaluations during which bone-to-implant contact (BIC) and bone density (BD) were evaluated Results BD and BIC were significantly higher at 12 weeks in the test group if the Implants were placed at the time of the sinus lift (p < 0 05) No difference was observed between the different implant systems or positions Conclusions The use of rhBMP-2 with PLPG-sponge increased BIC as well as BD in the augmented sinuses if compared to autologous bone Different implant systems and positions of the implants had no effect on BIC or BD (C) 2010 European Association for Cranio-Maxillo-Facial Surgery