Absorption of orally administered 65Zn by normal human subjects.
Absorption of orally administered 65Zn by normal human subjects.
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正常人类受试者口服 65Zn 的吸收。
DOI：
10.1093/ajcn/34.12.2648
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
R. Henkin
中科院分区：
文献类型：
--
作者：
R. Aamodt;W. Rumble;G. Johnston;E. J. Markley;R. Henkin
尽管几位研究人员对人体胃肠道 65Zn 吸收进行了研究，但这些数据对功能性锌状态评估的影响尚不清楚，因为研究的正常受试者数量有限。为了评估正常人的锌吸收情况，75 名受试者（31 名女性，44 名男性，年龄 18 至 84 岁）在禁食过夜后口服 10 微 Ci 载体的 65Zn。根据施用示踪剂后 7、14 和 21 天测量的全身保留计算的吸收率为 65 +/- 11%（平均值 +/- 1 SD），范围为 40 至 86%。将这些结果与患有多种疾病的患者的结果进行比较表明，患者表现出更广泛的吸收，并且在六项研究中的四项中，患者表现出平均锌吸收下降。这些大量正常人胃肠道锌吸收的结果为与表现出锌吸收异常的患者的数据进行更清晰的比较提供了基础。
Despite studies by several investigators of human gastrointestinal 65Zn absorption, implications of these data for evaluation of functional zinc status are unclear because limited numbers of normal subjects have been studied. To evaluated zinc absorption in normal humans, 75 subjects (31 women, 44 men, ages 18 to 84 yr) were given 10 micro Ci carrier-free 65Zn orally after an overnight fast. Absorption calculated from total body retention measured 7, 14, and 21 days after administration of tracer was 65 +/- 11% (mean +/- 1 SD), range from 40 to 86%. Comparison of these results with those for patients with a variety of diseases indicate that patients exhibit a wider range of absorption and, in four of six studies patients exhibit decreased mean zinc absorption. These results of gastrointestinal zinc absorption in a large number of normal humans offer a basis for a clearer comparison with data from patients who exhibit abnormalities of zinc absorption.