Hypercalcaemia during treatment of psoriasis with calcipotripl
Hypercalcaemia during treatment of psoriasis with calcipotripl
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卡泊三普治疗银屑病期间出现高钙血症
DOI：
10.1111/j.1365-2133.1994.tb03423.x
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发表时间：
1994
影响因子：
10.3
通讯作者：
M. Young
中科院分区：
文献类型：
--
作者：
S. Russell;M. Young
女性患者。然而，我们的病人从未使用过指甲油。纵向甲裂是由于甲基质黑色素细胞受到刺激而引起的，随后甲板中黑色素沉积增加。色素沉积可能是由正常无功能的基质黑色素细胞合成更多的黑色素引起的。或者是合成黑色素的基质黑色素细胞总数的增加。^在这两种情况下，黑素细胞可能是正常的，也可能是异常的。这是甲板独特的生长动态，导致线性图案的色素沉着。Mooney和Bennett“对甲周色素沉着和二甲胺环环素继发的纵向黑甲癣患者进行了甲基质活检。发现了一个良性的色斑。有证据表明，长期使用二甲胺四环素通过刺激黑色素细胞增加黑色素的产生。导致暴露在阳光下的区域出现泥褐色色素沉着。本例患者未进行活组织检查。事实上，二甲胺四环素可能诱发纵向黑甲癣的知识可以防止不必要的指甲组织活检。使用二甲胺四环素治疗的患者应注意皮肤和指甲色素变化的可能性。尽管停止治疗，色素沉着可能会持续很长时间。
female patients. However, our patient had never used nail polish. Longitudinal mehinonychia results from stimiikition of nail matrix melanocytes, with a subsequent increase in melanin deposition in the nail plate. Pigment deposition may result from greater melanin synthesis by normally nonfunctional matrix melanocytes. or from an increase in the total number of matrix melanocytes which synthesize melanin.''^ In either instance, melanocytes may be normal or abnormal.-"-' It is the unique growth dynamics of the nail plate which result in the linear pattern ol' pigmentation. Mooney and Bennett'' performed a nail matrix biopsy on a patient with periungual hyperpigmentation and longitudinal melanonychia secondary to minocyclinf. and found the presence of a benign lentigo. There is evidence suggesting that long-term use of minocycline increases melanin production by stimulation of melanocytes. causing the muddy-brown pigmentation in sun-exposed areas.A biopsy was not performed in our patient. Indeed, the knowledge that minocycline may induce longitudinal melanonychia may prevent unnecessary biopsy of the nail apparatus. Patients treated with minocycline should be warned of the possibility of cutaneous and nail pigmentary changes. Pigmentation may persist for a prolonged period, despite withdrawal of therapy.