Intrinsic Connectivity of Hippocampal Subfields in Normal Elderly and Mild Cognitive Impairment Patients
Intrinsic Connectivity of Hippocampal Subfields in Normal Elderly and Mild Cognitive Impairment Patients
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DOI：
10.1002/hbm.23704
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发表时间：
2017-10-01
影响因子：
4.8
通讯作者：
Chetelat, Gael
中科院分区：
文献类型：
--
作者：
de Flores, Robin;Mutlu, Justine;Chetelat, Gael
海马连接已被广泛描述，但海马子场的连接特异性及其在早期AD中的变化知之甚少。本研究的目的是突出健康老年人（HE）的海马亚区网络和遗忘症轻度认知功能障碍（aMCI）患者的变化。36例HE和27例aMCI患者接受了静息状态功能MRI扫描。在HE（使用高分辨率扫描上手动描绘的种子）中确定了双侧CA 1、CA 1（下托）和CA 2/3/4/DG的特异性内在连接，并在HE和aMCI之间进行了比较。与其他子场相比，CA 1与杏仁核和枕区的联系更强，CA 2/3/4/DG与左前扣带皮层、颞叶和枕区的联系更强，而CA 2/3/4/DG与角区、楔前叶、壳核、后扣带和额叶的联系更强。aMCI患者表现出大脑皮层网络（与额叶和后扣带回区域）内的连通性降低。我们的研究首次强调了HE中三个特定且不同的海马子区功能网络及其在aMCI中的改变。这些发现对于了解AD在认知缺陷和病变拓扑中的特异性非常重要，因为功能连接在这些过程中起作用。(C)2017 Wiley Periodicals，Inc.
Hippocampal connectivity has been widely described but connectivity specificities of hippocampal subfields and their changes in early AD are poorly known. The aim of this study was to highlight hippocampal subfield networks in healthy elderly (HE) and their changes in amnestic patients with mild cognitive impairment (aMCI). Thirty-six HE and 27 aMCI patients underwent resting-state functional MRI scans. Specific intrinsic connectivity of bilateral CA1, SUB (subiculum), and CA2/3/4/DG was identified in HE (using seeds derived from manually delineation on high-resolution scans) and compared between HE and aMCI. Compared to the other subfields, CA1 was more strongly connected to the amygdala and occipital regions, CA2/3/4/DG to the left anterior cingulate cortex, temporal, and occipital regions, and SUB to the angular, precuneus, putamen, posterior cingulate, and frontal regions. aMCI patients showed reduced connectivity within the SUB network (with frontal and posterior cingulate regions). Our study highlighted for the first time three specific and distinct hippocampal subfield functional networks in HE, and their alterations in aMCI. These findings are important to understand AD specificities in both cognitive deficits and lesion topography, given the role of functional connectivity in these processes. (C) 2017 Wiley Periodicals, Inc.