Stem Cells in Skin Regeneration, Wound Healing, and Their Clinical Applications.
Stem Cells in Skin Regeneration, Wound Healing, and Their Clinical Applications.
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DOI：
10.3390/ijms161025476
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发表时间：
2015-10-23
影响因子：
5.6
通讯作者：
Stojadinovic O
中科院分区：
文献类型：
--
作者：
Ojeh N;Pastar I;Tomic-Canic M;Stojadinovic O
皮肤是人体最大的器官，具有多种功能。干细胞是皮肤细胞的重要组成部分，是维持皮肤稳态和再生所不可缺少的。这些干细胞还有助于伤口修复，导致组织完整性和受损组织功能的恢复。不成功的伤口愈合过程通常导致不愈合的伤口。慢性伤口是由干细胞耗竭和各种其他细胞和分子机制引起的，其中许多机制仍然知之甚少。目前的慢性伤口治疗是有限的，因此正在寻求开发更好的治疗策略。成体干细胞作为许多皮肤病的潜在候选者正在获得认可。在这篇综述中，我们将讨论表皮和其他干细胞存在于皮肤中，并强调一些表皮干细胞和其他成体干细胞的治疗应用，作为工具的细胞/支架为基础的治疗非愈合伤口和其他皮肤疾病。我们还将讨论新兴的概念，并提供一些关于皮肤组织工程产品如何优化，以提供有效的治疗皮肤修复和再生的观点。
The skin is the largest organ of the body and has an array of functions. Skin compartments, epidermis, and hair follicles house stem cells that are indispensable for skin homeostasis and regeneration. These stem cells also contribute to wound repair, resulting in restoration of tissue integrity and function of damaged tissue. Unsuccessful wound healing processes often lead to non-healing wounds. Chronic wounds are caused by depletion of stem cells and a variety of other cellular and molecular mechanisms, many of which are still poorly understood. Current chronic wound therapies are limited, so the search to develop better therapeutic strategies is ongoing. Adult stem cells are gaining recognition as potential candidates for numerous skin pathologies. In this review, we will discuss epidermal and other stem cells present in the skin, and highlight some of the therapeutic applications of epidermal stem cells and other adult stem cells as tools for cell/scaffold-based therapies for non-healing wounds and other skin disorders. We will also discuss emerging concepts and offer some perspectives on how skin tissue-engineered products can be optimized to provide efficacious therapy in cutaneous repair and regeneration.