Human L3L4 intervertebral disc mean 3D shape, modes of variation, and their relationship to degeneration.
Human L3L4 intervertebral disc mean 3D shape, modes of variation, and their relationship to degeneration.
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DOI：
10.1016/j.jbiomech.2014.04.014
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发表时间：
2014-07-18
影响因子：
2.4
通讯作者：
Elliott, Dawn M.
中科院分区：
文献类型：
--
作者：
Peloquin, John M.;Yoder, Jonathon H.;Jacobs, Nathan T.;Moon, Sung M.;Wright, Alexander C.;Vresilovic, Edward J.;Elliott, Dawn M.
椎间盘力学受椎间盘形状和椎间盘退变的影响，两者相互影响；椎间盘力学在椎间盘退变的病因学中也有作用。有限元分析（FEA）是研究这些关系的有利工具，但椎间盘三维形状的有限数据迫使使用简化或单一受试者的几何形状，而个体间形状变化的影响仅在专门研究中进行调查。同样，大多数椎间盘形状随退变变化的数据是基于二维中矢状面图像，不能完全定义三维形状变化。因此，本研究的目的是量化个体间的三维椎间盘形状变化，使用统计形状模型将这种变化分类为独立发生的模式，并确定椎间盘形状与退变之间的相关性。对13具男性尸体的L3L4椎间盘进行MRI扫描，获得了椎间盘的三维形状。确定了平均圆盘形状和四种主要形状变化模式（代表90%的方差）。第一种模式代表椎间盘轴向面积，与退变显著相关（R2 = 0.44），表明退变椎间盘轴向面积较大。圆盘高度变化以三种不同的模式发生，每种模式也涉及非高度变化。统计形状模型为有限元分析提供了一个完全在三维中定义的平均L3L4盘形状，并使其方便地生成一组形状来表示个体间的总体变化。退化等级特定的形状也可以生成。为便于应用，将该模型纳入本文的补充内容。
Intervertebral disc mechanics are affected by both disc shape and disc degeneration, which in turn each affect the other; disc mechanics additionally have a role in the etiology of disc degeneration. Finite element analysis (FEA) is a favored tool to investigate these relationships, but limited data for intervertebral disc 3D shape has forced the use of simplified or single-subject geometries, with the effect of inter-individual shape variation investigated only in specialized studies. Similarly, most data on disc shape variation with degeneration is based on 2D mid-sagittal images, which incompletely define 3D shape changes. Therefore, the objective of this study was to quantify inter-individual disc shape variation in 3D, classify this variation into independently-occurring modes using a statistical shape model, and identify correlations between disc shape and degeneration. Three-dimensional disc shapes were obtained from MRI of 13 human male cadaver L3L4 discs. An average disc shape and four major modes of shape variation (representing 90% of the variance) were identified. The first mode represented disc axial area and was significantly correlated to degeneration (R2 = 0.44), indicating larger axial area in degenerate discs. Disc height variation occurred in three distinct modes, each also involving non-height variation. The statistical shape model provides an average L3L4 disc shape for FEA that is fully defined in 3D, and makes it convenient to generate a set of shapes with which to represent aggregate inter-individual variation. Degeneration grade-specific shapes can also be generated. To facilitate application, the model is included in this paper’s supplemental content.
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影响因子：
2.8
作者：
Benneker, LM;Heini, PF;Ito, K
通讯作者：
Ito, K
影响因子：
3
作者：
JOHNSTONE, B;URBAN, JPG;MENAGE, J
通讯作者：
MENAGE, J
影响因子：
3
作者：
Bono, Christopher M.;Khandha, Ashutosh;Garfin, Steven R.
通讯作者：
Garfin, Steven R.
DOI：
10.2106/00004623-197254030-00004
发表时间：
1972-01-01
影响因子：
5.3
作者：
FARFAN, HF;HUBERDEAU, RM;DUBOW, HI
通讯作者：
DUBOW, HI
影响因子：
3
作者：
Lee, CK;Kim, EY;Goel, VK
通讯作者：
Goel, VK