Domain coupling in asymmetric lipid bilayers.

Domain coupling in asymmetric lipid bilayers.
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不对称脂质双层中的域耦合。

DOI:
10.1016/j.bbamem.2008.09.003
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发表时间:
2009-01
影响因子:
3.4
通讯作者:
Tamm, Lukas K.
Tamm, Lukas K.
中科院分区:
生物学3区
文献类型:
--
作者:
Kiessling, Volker;Wan, Chen;Tamm, Lukas K.

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生物膜是脂质、蛋白质和胆固醇的异质组装体,其被组织为具有嵌入蛋白质的脂质的不对称双分子小叶。通过胆固醇浓度的调节,脂质和蛋白质可以分离成两个或多个具有不同物理性质的液相,这些液相可以共存于同一膜中。在这篇综述中,我们总结了最近的进展,这种情况下,可以重新创建一个支持的双层格式,以及如何使用该系统已被用来证明脂质组合物中的有序脂质结构域的诱导是典型的内小叶的脂质组合物,是典型的外小叶的哺乳动物质膜。显示蛋白质差异靶向这种诱导的内小叶结构域。
Biological membranes are heterogeneous assemblies of lipids, proteins, and cholesterol that are organized as asymmetric bimolecular leaflets of lipids with embedded proteins. Modulated by the concentration of cholesterol lipids and proteins may segregate into two or more liquid phases with different physical properties that can coexist in the same membrane. In this review, we summarize recent advances on how this situation can be recreated in a supported bilayer format and how this system has been used to demonstrate the induction of ordered lipid domains in lipid compositions that are typical for the inner leaflet by lipid compositions that are typical for the outer leaflet of mammalian plasma membranes. Proteins are shown to differentially target such induced inner leaflet domains.
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