NF90 in posttranscriptional gene regulation and microRNA biogenesis.
NF90 in posttranscriptional gene regulation and microRNA biogenesis.
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DOI：
10.3390/ijms140817111
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发表时间：
2013-08-19
影响因子：
5.6
通讯作者：
Imoto I
中科院分区：
文献类型：
--
作者：
Masuda K;Kuwano Y;Nishida K;Rokutan K;Imoto I
基因表达模式由转录和翻译调节（TTR）RNA结合蛋白（RBP）有效调节。TTR-RBP在转录后水平控制基因表达，如前mRNA剪接、mRNA胞质输出、周转、储存和翻译。已知双链RNA结合蛋白（DSRBPs）调节许多细胞代谢过程，包括转录控制、翻译控制、mRNA加工和定位。核因子90（NF 90）是一种DSRBPs，在脊椎动物组织中大量表达，参与RNA代谢的许多方面。NF 90最初是作为DNA结合复合物的组分纯化的，该DNA结合复合物结合白细胞介素2启动子中的抗原识别应答元件2。最近的研究为我们提供了有趣的见解，其可能的生理作用在RNA代谢，包括转录，降解和翻译。此外，研究表明NF 90调节microRNA的表达。本文就NF 90在转录后基因调控和microRNA生物合成中的作用作一综述。
Gene expression patterns are effectively regulated by turnover and translation regulatory (TTR) RNA-binding proteins (RBPs). The TTR-RBPs control gene expression at posttranscriptional levels, such as pre-mRNA splicing, mRNA cytoplasmic export, turnover, storage, and translation. Double-stranded RNA binding proteins (DSRBPs) are known to regulate many processes of cellular metabolism, including transcriptional control, translational control, mRNA processing and localization. Nuclear factor 90 (NF90), one of the DSRBPs, is abundantly expressed in vertebrate tissue and participates in many aspects of RNA metabolism. NF90 was originally purified as a component of a DNA binding complex which binds to the antigen recognition response element 2 in the interleukin 2 promoter. Recent studies have provided us with interesting insights into its possible physiological roles in RNA metabolism, including transcription, degradation, and translation. In addition, it was shown that NF90 regulates microRNA expression. In this review, we try to focus on the function of NF90 in posttranscriptional gene regulation and microRNA biogenesis.
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