Stress and memory: Opposing effects of glucocorticoids on memory consolidation and memory retrieval
Stress and memory: Opposing effects of glucocorticoids on memory consolidation and memory retrieval
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DOI：
10.1006/nlme.2002.4080
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发表时间：
2002-11-01
影响因子：
2.7
通讯作者：
Roozendaal, B
中科院分区：
文献类型：
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作者：
Roozendaal, B
众所周知，压力事件后肾上腺皮质分泌的糖皮质激素会影响认知表现。一些研究发现糖皮质激素可以增强记忆力。然而，许多研究报告糖皮质激素对记忆功能有损害作用。本文回顾了该实验室关于糖皮质激素对大鼠特定记忆阶段（即记忆巩固和记忆检索）的急性影响的最新研究结果。有证据表明，糖皮质激素激活对认知的影响很大程度上取决于所研究的不同记忆阶段。训练后激活涉及糖皮质激素受体的糖皮质激素敏感通路可增强记忆巩固，其模式与之前描述的肾上腺儿茶酚胺的模式高度相似。此外，与儿茶酚胺对记忆巩固的影响类似，糖皮质激素对记忆巩固的影响取决于杏仁核基底外侧复合体的去甲肾上腺素能激活以及与其他大脑区域的相互作用。相比之下，高循环糖皮质激素水平或将糖皮质激素受体激动剂注入海马后，记忆检索过程通常会受到损害。提出的假设是，糖皮质激素对记忆巩固和记忆检索的这些明显的双重作用可能是相关的，并且杏仁核的基底外侧复合体是记忆调节系统中的关键结构，该系统与其他大脑区域一起调节压力和糖皮质激素对记忆巩固和记忆检索的影响。 (C) 2002 年爱思唯尔科学（美国）。
It is well established that glucocorticoid hormones, secreted by the adrenal cortex after a stressful event, influence cognitive performance. Some studies have found glucocorticoid-induced memory enhancement. However, many studies have reported impairing effects of glucocorticoids on memory function. This paper reviews recent findings from this laboratory on the acute effects of glucocorticoids in rats on specific memory phases, i.e., memory consolidation and memory retrieval. The evidence suggests that the consequences of glucocorticoid activation on cognition depend largely on the different memory phases investigated. Posttraining activation of glucocorticoid-sensitive pathways involving glucocorticoid receptors enhances memory consolidation in a pattern highly similar to that previously described for adrenal catecholamines. Also, similar to catecholamine effects on memory consolidation, glucocorticoid influences on memory consolidation depend on noradrenergic activation of the basolateral complex of the amygdala and interactions with other brain regions. By contrast, memory retrieval processes are usually impaired with high circulating levels of glucocorticoids or following infusions of glucocorticoid receptor agonists into the hippocampus. The hypothesis is proposed that these apparently dual effects of glucocorticoids on memory consolidation and memory retrieval might be related and that the basolateral complex of the amygdala is a key structure in a memory-modulatory system that regulates, in concert with other brain regions, stress and glucocorticoid effects on both memory consolidation and memory retrieval. (C) 2002 Elsevier Science (USA).