Proton magnetic resonance spectroscopy changes after antipsychotic treatment.
Proton magnetic resonance spectroscopy changes after antipsychotic treatment.
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DOI：
10.2174/0929867311320030013
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发表时间：
2013
影响因子：
4.1
通讯作者：
A. Szulc;B. Galińska-Skok;N. Waszkiewicz;D. Bibułowicz;B. Konarzewska;E. Tarasów
中科院分区：
文献类型：
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作者：
A. Szulc;B. Galińska-Skok;N. Waszkiewicz;D. Bibułowicz;B. Konarzewska;E. Tarasów
质子磁共振波谱（(1)hmrs）可以在体内观察大脑功能。几种脑代谢物可以通过(1)H MRS测量：n -乙酰天冬氨酸（NAA）、含胆碱的化合物（Cho）、肌醇（mI）和谷氨酸（Glu）、谷氨酰胺（Gln）和GABA（一起作为Glx复合物或单独）。(1) hmrs测量在精神分裂症等精神障碍中发现异常。在这里，我们特别回顾了抗精神病药物对脑代谢的影响，通过(1)H mrs检测。我们系统地回顾了现有文献，发现了27项研究，16项治疗前后研究和11项横断面研究。他们大多讨论抗精神病药物对精神分裂症的影响，主要集中在NAA的改变上。后续研究表明，抗精神病药物可能通过增加特定脑区（额叶和丘脑）的NAA水平起作用，特别是在短时间观察期间。这种现象似乎在长时间观察后就消失了。其他研究表明，谷氨酸含量随着疾病的持续时间而下降，这表明精神分裂症患者大脑中存在神经退行性过程以及抗精神病药物的影响。以上结果是根据最新的理论在该领域的影响，说明抗精神病药物(1)HMRS措施。
Proton magnetic resonance spectroscopy ((1)H MRS) enables the observation of brain function in vivo. Several brain metabolites can be measured by the means of (1)H MRS: N-acetylaspartate (NAA), choline containing compounds (Cho), myo-inositol (mI) and glutamate (Glu), glutamine (Gln) and GABA (together as Glx complex or separately). (1)H MRS measures have been found to be abnormal in psychotic disorders such as schizophrenia. Here we specifically review the influence exerted by antipsychotic drugs on brain metabolism, as detected by (1)H MRS. We systematically reviewed the available literature and uncovered 27 studies, 16 before-after treatment and 11 cross-sectional. Most of them addressed the effects of antipsychotics in schizophrenia and mainly focusing on NAA alterations. Follow up studies indicated antipsychotic drugs may act by increasing NAA levels in selected brain areas (the frontal lobe and thalamus), especially during the short-time observation. This phenomenon seems to vanish after longer observation. Other studies indicated that glutamate measures are decreasing along with the duration of the disease, suggesting both a neurodegenerative process present in schizophrenic brain as well as an influence of antipsychotics. The above results were reviewed according to the most recent theories in the field accounting for the impact of antipsychotics (1)HMRS measures.