Increased serum matrix metalloproteinase-9 in neuromyelitis optica: Implication of disruption of blood-brain barrier
Increased serum matrix metalloproteinase-9 in neuromyelitis optica: Implication of disruption of blood-brain barrier
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DOI：
10.1016/j.jneuroim.2011.04.009
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发表时间：
2011-07-01
影响因子：
3.3
通讯作者：
Takahashi, Toshiyuki
中科院分区：
文献类型：
--
作者：
Hosokawa, Takafumi;Nakajima, Hideto;Takahashi, Toshiyuki
基质金属蛋白酶-9（MMP-9）通过破坏血脑屏障（BBB）在一些神经炎性疾病中发挥重要作用。为探讨MMP-9在视神经肌萎缩症（NMO）中的致病性，检测了13例NMO患者、15例多发性硬化（MS）患者和14例健康对照者血清和脑脊液中MMP-9的浓度，并与临床和实验室指标进行相关性分析。血清MMP-9浓度在NMO组显著高于MS组和对照组，并与EDSS评分、CSF/血清白蛋白比值和CSF IL-8浓度相关。我们的研究结果表明，MMP-9，促进了IL-8的激活，通过BBB破坏在NMO的发病机制中起着至关重要的作用。(C)2011 Elsevier B. V.保留所有权利。
Matrix metalloproteinase-9 (MMP-9) plays an important role in some neuroinflammatory diseases through the blood-brain barrier (BBB) disruption. To investigate the pathogenicity of MMP-9 in neuromyelitis optica (NMO), serum and CSF MMP-9 concentrations were measured in 13 NMO and 15 multiple sclerosis (MS) patients and 14 healthy controls, and correlated with clinical and laboratorial parameters. Serum MMP-9 concentrations were significantly higher in NMO than MS and controls, and correlated with EDSS score, CSF/serum albumin ratio, and CSF IL-8 concentrations. Our results indicate that MMP-9, promoted by elevated IL-8 activation, plays a crucial role in the pathogenesis of NMO through the BBB disruption. (C) 2011 Elsevier B.V. All rights reserved.