Perinatal Mental Health in Women with Polycystic Ovary Syndrome: A Cross-Sectional Analysis of an Australian Population-Based Cohort
Perinatal Mental Health in Women with Polycystic Ovary Syndrome: A Cross-Sectional Analysis of an Australian Population-Based Cohort
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DOI：
10.3390/jcm8122070
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发表时间：
2019-12-01
影响因子：
3.9
通讯作者：
Joham, Anju E.
中科院分区：
文献类型：
--
作者：
Chau Thien Tay;Teede, Helena J.;Joham, Anju E.
多囊卵巢综合征（PCOS）妇女有许多与围产期精神障碍相关的危险因素，但这方面的研究很少。本研究旨在比较多囊卵巢综合征与非多囊卵巢综合征妇女围产期常见精神障碍的患病率，探讨多囊卵巢综合征与围产期常见精神障碍的关系。我们进行了一项横断面研究，对1973年至1978年出生的5239名妇女的自我报告数据在澳大利亚妇女健康纵向研究。与未报告PCOS的妇女相比，报告PCOS的妇女产前抑郁的患病率较高（8.9%vs.4.4%，p < 0.001），产前焦虑（11.7%对5.6%，p < 0.001）、产后抑郁（26.8%对18.6%，p < 0.001）和产后焦虑（18.4%对12.0%，p < 0.001）。在控制了社会人口学和生活方式因素、生育史、产科并发症和既存抑郁和焦虑后，PCOS与产前抑郁和/或焦虑呈正相关（校正比值比1.8，95%置信区间1.2-2.6），但与产后抑郁和/或焦虑无关。一般围产期指南目前不承认PCOS是一个危险因素，国际循证PCOS指南指出这方面的证据不足。本文讨论了文献中的差距，并强调需要筛查常见的围产期精神障碍的妇女与PCOS。
Women with polycystic ovary syndrome (PCOS) have many risk factors associated with perinatal mental disorders, but research in this area is scarce. This study aims to compare the prevalence of common perinatal mental disorders in women with and without PCOS, and examine the relationship between PCOS and common perinatal mental disorders. We performed a cross-sectional study on self-reported data of 5239 women born between 1973 to 1978 in the Australian Longitudinal Study on Women's Health. Compared with women not reporting PCOS, women reporting PCOS had higher prevalence of antenatal depression (8.9% vs. 4.4%, p < 0.001), antenatal anxiety (11.7% vs. 5.6%, p < 0.001), postnatal depression (26.8% vs. 18.6%, p < 0.001) and postnatal anxiety (18.4% vs. 12.0%, p < 0.001). PCOS was positively associated with antenatal depression and/or anxiety (adjusted odds ratio 1.8, 95% confidence interval 1.2-2.6) but not postnatal depression and/or anxiety after controlling for sociodemographic and lifestyle factors, reproductive history, obstetric complications and pre-existing depression and anxiety. General perinatal guidelines currently do not recognize PCOS as a risk factor and the international evidence based PCOS guideline noted inadequate evidence in this area. This paper addresses the gap in literature and highlights the need to screen for common perinatal mental disorders in women with PCOS.