The functional neuroanatomy of episodic and semantic autobiographical remembering: A prospective functional MRI study
The functional neuroanatomy of episodic and semantic autobiographical remembering: A prospective functional MRI study
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DOI：
10.1162/0898929042568587
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发表时间：
2004-11-01
影响因子：
3.2
通讯作者：
McIntosh, AR
中科院分区：
文献类型：
--
作者：
Levine, B;Turner, GR;McIntosh, AR
自传体记忆包括由可分离的意识状态介导的情景和语义成分，一个促进过去特定时刻的自我体验，另一个涉及不需要“心理时间旅行”的自我知识。这些成分很难通过回顾性的自传刺激收集来分离。在这项研究中，我们操纵传记的情节/语义的区别在前瞻性收集自传刺激。在几个月的时间里，参与者录制了记录特定事件，重复事件和世界知识的录音。这些记录后来在功能性MRI扫描期间回放给参与者。结果表明，重叠，但不同的大脑活动模式对应于情节和语义自传体记忆。情景和语义自传体记忆都涉及与自我参照相关的左前内侧前额叶皮层，但情景条件在更大程度上这样做。情节条件独特从事内侧颞，后扣带回，间脑区与远程记忆恢复。情景条件下，右侧颞顶叶皮层参与空间语境和注意力定向的重建;语义条件下，左侧颞顶叶和顶叶额叶系统参与自我中心空间加工和自上而下的注意力控制。情景回忆也与情绪边缘区的抑制有关。这些研究结果支持情节和语义自传体记忆之间的功能性神经解剖分离，这两种形式的自传体记忆中的一种与不成比例的损伤的健忘症综合征提供了一致性。
Autobiographical memory comprises episodic and semantic components mediated by dissociable states of consciousness, one promoting the experience of the self at a specific moment in the past, and the other involving self-knowledge that does not require "mental time travel.'' These components can be difficult to dissociate using retrospective autobiographical stimuli collection. In this study, we manipulated biographical the episodic/semantic distinction within prospectively collected autobiographical stimuli. Over several months, participants made recordings documenting specific episodes, repeated episodes, and world knowledge. These recordings were later played back to participants during scanning with functional MRI. The results indicated overlapping but distinct patterns of brain activity corresponding to episodic and semantic autobiographical memory. Both episodic and semantic autobiographical memory engaged the left anteromedial prefrontal cortex associated with self-reference, but the episodic condition did so to a greater degree. The episodic condition uniquely engaged the medial temporal, posterior cingulate, and diencephalic regions associated with remote memory recovery. Whereas the episodic condition engaged the right temporo-parietal cortex involved in reconstruction of spatial context and attentional orienting, the semantic condition engaged the left temporo-parietal and parieto-frontal systems involved in egocentric spatial processing and top-down attentional control. Episodic recollection was also associated with suppression of emotional paralimbic regions. These findings support a functional neuroanatomical dissociation between episodic and semantic autobiographical memory, providing concordance to amnesic syndromes with disproportionate impairment in one of these two forms of autobiographical memory.