Microdistribution and localized dosimetry of 241Am in bones of beagle dogs.
Microdistribution and localized dosimetry of 241Am in bones of beagle dogs.
复制标题
比格犬骨骼中 241Am 的微分布和局部剂量测定。
DOI：
10.1080/09553008414551221
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Jee,WS
中科院分区：
文献类型：
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作者：
Polig,E;Smith,JM;Jee,WS
用计算机控制的显微镜分光光度计分析了~(241)Am在7只比格犬骨骼中的微量分布。注射剂量在102.5kBq/kg~165kBq/kg之间的动物中，有4只在注射后7~20d内被处死，3只注射32kBq/kg~34.0kBq/kg的动物在注射后1300~1569d内被处死。利用光度扫描技术，得到了几个解剖区域的~(241)Am浓度、比表面活度及其变化、剂量率、累积辐射剂量、埋深和形态参数。邻近表面的0-10μm骨髓带的剂量率是平均骨骼剂量的8.6-15.7倍。最初沉积到衬里细胞的累积辐射剂量估计在87至252Gy.后期处死动物的平均埋藏深度约为8μm。形态计量学参数显示，这些动物发生了辐射损伤，导致骨小梁结构异常。比表面活性与局部周转率之间存在正相关关系。
The microdistribution of241Am in selected bones of seven beagle dogs was analysed using a computer controlled microscope photometer. Four of the animals receiving between 102·5 and 165 kBq/kg were killed between 7 and 20 days after injection, and three animals receiving 32·9–34·0 kBq/kg were killed between 1300 and 1569 days. Using the photometric scanning technique, the concentrations of241Am in several anatomical regions, as well as the specific surface activities and their variations, dose rates, accumulated radiation doses, burial depths and morphometric parameters, were derived. Dose rates to the 0–10 μm marrow band adjacent to surfaces were found to be between 8·6 and 15·7 times higher than the average skeletal dose. Accumulated radiation doses from initial deposits to lining cells were estimated to be between 87 and 252 Gy. The average burial depth in the animals killed at later times was around 8 μm. Morphometric parameters showed that radiation damage occurred in these animals, resulting in abnormal trabecular architecture. A positive correlation between specific surface activity and local turnover rates was established.