Presentation, treatment, and outcome of oral cavity cancer: A national cancer data base report
Presentation, treatment, and outcome of oral cavity cancer: A national cancer data base report
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DOI：
10.1002/hed.10004
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发表时间：
2002-02-01
影响因子：
2.9
通讯作者：
Hoffman, HT
中科院分区：
文献类型：
--
作者：
Funk, GF;Karnell, LH;Hoffman, HT
背景口腔癌已被确定为一个重大的公共卫生威胁。系统评价这种疾病对美国人口的影响对卫生保健提供者和政策制定者非常重要。这项研究使用国家癌症数据库（NCDB）来评估人口统计学和疾病特征，治疗和美国口腔癌患者生存率之间的关系。在1985年至1996年诊断的患者中，有58，976人是从NCDB中提取的。对选定的交叉表进行方差分析，并使用相对生存率计算结果。患者的中位年龄为64.0岁。男性占60.2%。病理诊断为鳞状细胞癌（SCC）的病例占86.3%。年轻的病人有。非鳞状细胞癌的发生率更高，这与这些患者的生存率有关。非裔美国人（与收入无关）、低收入患者和高级别疾病患者更常发生晚期SCC。老年患者、男性和非裔美国人SCC病例的5年相对生存率较低。这项研究解决了许多与口腔癌有关的问题，这些问题以前在文献中已经讨论过。NCDB中大量病例的人口统计学、部位、分期、组织学和生存数据可以准确描述美国口腔癌的当代状况。(C)2002年John Wiley Sons，Inc.
Background. Oral cancer has been identified as a significant public health threat. Systematic evaluation of the impact of this disease on the US population is of great importance to health care providers and policy makers.Methods. This study used the National Cancer Data Base (NCDB) to evaluate associations between demographic and disease characteristics, treatment, and survival for patients: with oral cavity cancer in the United States. Of patients diagnosed between 1985 and 1996, 58,976 were extracted from the NCDB. ANOVAs were performed on selected cross-tabulations, and relative survival was used to calculate outcome.Results. Median age of patients was 64.0 years. Men made up 60.2% of patients. Pathologic diagnosis was squamous cell carcinoma (SCC) in 86.3% of cases. Younger patients had a. much higher frequency of non-SCC, and this was related to survival in these patients. African-Americans (independent of income), lower income patients, and patients with higher grade disease were seen more frequently with advanced-stage SCC. Five-year relative survival for SCC cases was lower for older patients, men, and African-Americans.Conclusions. This study addressed many issues related to oral cancer that have been previously discussed in the literature. The demographic, site, stage, histologic, and survival data available for this large number of cases in the NCDB allowed an accurate characterization of the contemporary status of oral cancer in the United States. (C) 2002 John Wiley Sons, Inc.