Recovery of bone density in women who stop using medroxyprogesterone acetate
Recovery of bone density in women who stop using medroxyprogesterone acetate
复制标题
停止使用醋酸甲羟孕酮的女性骨密度恢复
作者：
Tim Cundy;J. Cornish;M. Evans;Helen Roberts;Ian R. Reid
为了确定使用醋酸甲羟孕酮的人的骨密度丢失是否可逆，在三组妇女中进行了一项比较研究。第一组包括14名妇女，她们使用避孕药至少3年，然后停止使用。第二组是22名长期吸毒者，第三组包括18名从未使用过该药物的女性作为对照组。在停药后，第1组的所有女性都恢复了雌激素的产生。每名女性都进行了两次骨密度测量。第一次测量时，第1组和第2组的腰椎密度比对照组平均低9%。然而，在第二次测量中，第一组的腰椎密度显著增加，而其他组的腰椎密度保持不变。股骨颈密度无明显变化。来自第一组的8名妇女在停药两年后进行的额外测量显示，腰椎骨密度进一步显着增加。因此，结论是骨密度下降是可逆的，即使在女性在停药后体重显著下降的情况下也是如此。
In order to determine whether the loss in bone density seen in users of depot medroxyprogesterone acetate is reversible, a comparative study was undertaken in three groups of women. Group 1 consisted of 14 women who had used the contraceptive for at least 3 years and then discontinued use. Group 2 was 22 longterm users, and Group 3 contained 18 women who had never used the drug and served as controls. Estrogen production resumed in all of the Group 1 women after discontinuation. Two bone density measurements were taken twice in each woman. At first measurement, lumbar spine density was an average of 9% lower in Groups 1 and 2 than in controls. At the second measurement, however, lumbar spine density had significantly increased in Group 1 while it remained the same for the other groups. No significant changes in femoral neck density were observed. Additional measurements in 8 women from Group 1 taken 2 years after discontinuation revealed a further significant increase in lumbar spine bone density. Thus, it was concluded that bone density loss is reversible, even in cases where women experience a significant weight loss after discontinuation.
老年人酗酒。
DOI：
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发表时间：
1990
期刊：
Comprehensive therapy
影响因子：
--
作者：
Beresford,TP;Blow,FC;Brower,KJ
通讯作者：
Brower,KJ
未经治疗的高催乳素血症的自然史：前瞻性分析。
DOI：
10.1210/jcem-68-2-412
发表时间：
1989
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Schlechte,J;Dolan,K;Sherman,B;Chapler,F;Luciano,A
通讯作者：
Luciano,A