Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo.
Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo.
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调节性T细胞在体内抑制CD4+ T细胞和树突状细胞之间的稳定接触。
DOI：
10.1084/jem.20050783
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发表时间：
2006-03-20
影响因子：
15.3
通讯作者：
Dustin, Michael L
中科院分区：
文献类型：
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作者：
Tadokoro, Carlos E;Shakhar, Guy;Shen, Shiqian;Ding, Yi;Lino, Andreia C;Maraver, Antonio;Lafaille, Juan J;Dustin, Michael L
调节性T（T reg）细胞对免疫反应具有强大的下调作用，但尚不清楚它们在体内如何发挥作用。使用活体双光子激光扫描显微镜，我们确定，在T reg细胞的情况下，淋巴结内的自身抗原特异性T细胞的运动减少，T细胞和抗原负载的树突状细胞（DC）之间的接触持续时间较长。因此，T reg细胞可以通过在DC引发初始T细胞期间减弱稳定接触的建立来对免疫应答发挥早期作用。
Regulatory T (T reg) cells exert powerful down-modulatory effects on immune responses, but it is not known how they act in vivo. Using intravital two-photon laser scanning microscopy we determined that, in the absence of T reg cells, the locomotion of autoantigen-specific T cells inside lymph nodes is decreased, and the contacts between T cells and antigen-loaded dendritic cells (DCs) are of longer duration. Thus, T reg cells can exert an early effect on immune responses by attenuating the establishment of stable contacts during priming of naive T cells by DCs.