Prognostic factors in advanced synovial sarcoma: an analysis of 104 patients treated at the Royal Marsden Hospital
Prognostic factors in advanced synovial sarcoma: an analysis of 104 patients treated at the Royal Marsden Hospital
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DOI：
10.1093/annonc/mdi082
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发表时间：
2005-03-01
影响因子：
50.5
通讯作者：
Judson, IR
中科院分区：
文献类型：
--
作者：
Spurrell, EL;Fisher, C;Judson, IR
目的：从文献中明确滑膜肉瘤诊断的关键预后因素。关于晚期疾病的预后参数的数据很少。我们的目的是专门研究一组晚期滑膜肉瘤患者，并确定潜在的预后因素。患者和方法：1978年至2003年间，从皇家马斯登医院的肉瘤数据库中发现了104例晚期滑膜肉瘤患者。回顾性分析患者资料。大多数患者在诊断时年龄在20至50岁之间。在分析时，71名患者已经死亡。92例患者接受化疗以治疗晚期疾病（最常见的是阿霉素+异环磷酰胺）。结果：发展为晚期疾病后的中位生存期为22个月。晚期疾病患者生存的预测因子是年龄
Aims: Key prognostic factors at diagnosis of synovial sarcoma are well defined from the literature. There are few data regarding prognostic parameters in the setting of advanced disease. Our aim was to look specifically at a cohort of patients with advanced synovial sarcoma and to identify potential prognostic factors.Patients and methods: One hundred and four patients with advanced synovial sarcoma were identified from the Royal Marsden Hospital's sarcoma database between 1978 and 2003. Patient data were analysed retrospectively. Most patients were aged between 20 and 50 years at diagnosis. Seventy-one patients were deceased at the time of analysis. Ninety-two patients received chemotherapy for management of advanced disease (most commonly doxorubicin + ifosfamide).Results: Median survival following development of advanced disease was 22 months. Predictors of survival with advanced disease were age