Does birth weight predict adult serum cortisol concentrations? Twenty-four-hour profiles in the United Kingdom 1920-1930 Hertfordshire birth cohort
Does birth weight predict adult serum cortisol concentrations? Twenty-four-hour profiles in the United Kingdom 1920-1930 Hertfordshire birth cohort
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DOI：
10.1210/jc.87.5.2001
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发表时间：
2002-05-01
影响因子：
5.8
通讯作者：
Hindmarsh, P
中科院分区：
文献类型：
--
作者：
Fall, CHD;Dennison, E;Hindmarsh, P
低出生体重和婴儿期体重与成人胰岛素抵抗和2型糖尿病有关。一个被提出的机制是通过子宫内营养不良对下丘脑-垂体-肾上腺轴进行编程，导致皮质醇浓度持续升高。我们检查了24小时血清皮质醇的配置文件（样本每20分钟）在83个健康的老年男性和女性的出生体重和婴儿体重记录。从这些配置文件中得出的变量包括谷，峰，曲线下面积浓度;发病时间，上升率，持续时间和清晨皮质醇上升的峰值;餐后分泌;和分泌的规律性（近似熵）。这些参数均与出生体重、1岁时体重或出生至1岁时体重SD评分变化无关。与其他研究一致，0730-0900 h皮质醇浓度在出生体重较低的男性和女性中较高，尽管这在统计学上不显著（P = 0.08）。我们的研究结果并不支持这样的假设，即子宫内和婴儿生长的减少与老年时皮质醇浓度的持续升高有关。对下丘脑-垂体-肾上腺轴的程序性作用可能影响反应性而不是静息分泌。
Low birth weight and weight in infancy are associated with adult insulin resistance and type 2 diabetes. A proposed mechanism is programming of the hypothalamic-pituitary-adrenal axis by intrauterine undernutrition, leading to persistently elevated cortisol concentrations. We examined 24-h serum cortisol profiles (samples every 20 min) in 83 healthy elderly men and women whose birth weight and infant weight were recorded. Variables derived from these profiles included trough, peak, and area under the curve concentrations; the time of onset, rate of rise, duration, and peak of the early morning cortisol rise; postprandial secretion; and regularity of secretion (approximate entropy). None of these parameters was related to birth weight, weight at 1 yr, or change in weight SD score between birth and 1 yr. Consistent with other studies, 0730-0900 h cortisol concentrations were higher in men and women of lower birth weight, although this was not statistically significant (P = 0.08). Our findings do not support the hypothesis that reduced intrauterine and infant growth are associated with continuously raised cortisol concentrations in old age. Programmed effects on the hypothalamic-pituitary-adrenal axis may influence reactivity rather than resting secretion.