Practical model description of peripheral neural excitation in cochlear implant recipients: 5. Refractory recovery and facilitation
Practical model description of peripheral neural excitation in cochlear implant recipients: 5. Refractory recovery and facilitation
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DOI：
10.1016/j.heares.2008.11.007
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发表时间：
2009-02-01
期刊：
影响因子：
2.8
通讯作者：
Cohen, Lawrence T.
中科院分区：
文献类型：
--
作者：
Cohen, Lawrence T.
在本文中，研究了对短脉冲间隔电刺激的神经反应。使用具有相对于探针脉冲的宽范围电流的掩蔽脉冲来记录电诱发复合动作电位（ECAP）的不应恢复。使用神经响应遥测 (TM) (NRT (TM)) 系统记录植入 Nucleus (R) 24 人工耳蜗植入系统（三个采用直电极阵列，两个采用 Contour (TM) 电极阵列）的受试者的 ECAP。利用先前在该系列的第四个吹笛者中获得的非难熔参数和双参数神经难熔恢复函数，将该模型拟合到 ECAP 恢复数据，用于掩蔽器电流相对于探头电流较高且假设掩蔽几乎完全的情况。在一个探头电流下拟合的一对难熔参数使模型能够很好地描述不同探头电流的 ECAP 恢复函数。通过将实验恢复函数与仅包括不应行为的建模函数进行比较，量化了掩蔽器相对于探针的不同电流对恢复函数的促进贡献。该模型应该提供改进人工耳蜗语音处理算法的方法，允许系统地合并有关电刺激神经反应的附加信息。 (C) 2008 Elsevier B.V. 保留所有权利。
In this paper the neural response to electrical stimulation with short inter-pulse intervals was examined. The refractory recovery of the electrically-evoked compound action potential (ECAP) was recorded using masker pulses with a wide range of currents relative to the probe pulse. The ECAP was recorded in subjects implanted with the Nucleus (R) 24 cochlear implant system (three with straight and two with Contour (TM) electrode arrays), using the Neural Response Telemetry (TM) (NRT (TM)) system. Employing the non-refractory parameters previously obtained in the fourth piper of the series and a two-parameter neural refractory recovery function, the model was fitted to ECAP recovery data for a case where the masker current was high relative to that of the probe and masking assumed to be almost complete. A single pair of refractory parameters, fitted at one probe current, allowed the model to describe quite well the ECAP recovery functions for different probe currents. Facilitatory contributions to the recovery functions, for differing current of masker relative to probe, were quantified by comparing experimental recovery functions with modeled functions that included only refractory behavior. The model should provide the means to improve speech processing algorithms for cochlear implants, by allowing the systematic incorporation of additional information concerning the neural response to electrical stimulation. (C) 2008 Elsevier B.V. All rights reserved.