Gender issues in transplantation
Gender issues in transplantation
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DOI：
10.1213/ane.0b013e318163feaf
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发表时间：
2008-07-01
影响因子：
5.7
通讯作者：
Csete, Marie
中科院分区：
文献类型：
--
作者：
Csete, Marie
临床移植中性别不匹配的影响已经被认识到半个世纪了。但临床移植中的性别问题不仅影响免疫学方面的问题，还会在多个层面上影响结果。许多导致移植的疾病主要表现在一个性别上。器官捐赠模式一直由女性成为活体捐赠者的更大趋势所决定。移植的机会可能受到移植人员与女性与男性候选人互动中的微妙之处的影响。在干细胞移植的新领域，男性和女性成体干细胞的功能差异可能有助于揭示固体器官移植结果的性别差异。这篇综述强调了与移植有关的性别问题，目的是优化对所有移植患者的护理。
The effects of gender mismatch in clinical transplantation have been recognized for half a century. But gender issues in clinical transplantation affect outcomes at many levels beyond immunologic concerns. Many diseases leading to transplantation are predominantly expressed in one gender. Organ donation patterns have consistently been defined by a greater tendency of women to be live donors. Access to transplantation may be affected by subtleties in the interactions of transplant personnel with women versus men candidates. In the new field of stem-cell transplantation, functional differences in male versus female adult stem cells may shed light on gender differences in outcomes for solid organ transplantation. This review highlights gender issues related to transplantation with a goal of optimizing the care of all transplant patients.