Early changes in the skin microcirculation and muscle metabolism of the diabetic foot
Early changes in the skin microcirculation and muscle metabolism of the diabetic foot
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DOI：
10.1016/s0140-6736(05)67696-9
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发表时间：
2005-11-12
期刊：
影响因子：
168.9
通讯作者：
Veves, A
中科院分区：
文献类型：
--
作者：
Greenman, RL;Panasyuk, S;Veves, A
背景 糖尿病足的大血管和微循环的变化对于足部溃疡的发展以及随后的现有溃疡的愈合失败很重要。我们研究了下肢的氧输送和肌肉代谢是否是糖尿病足病的因素。 方法 我们研究了 108 名患者（21 名未患有糖尿病的对照个体、36 名没有神经病变的糖尿病患者、以及 51 名同时患有糖尿病和神经病变的患者）。我们使用医学高光谱成像 (MHSI) 来研究前臂和足部的血红蛋白饱和度（SHSIO2；总血红蛋白中氧合血红蛋白的百分比[氧合血红蛋白和脱氧血红蛋白的总和]）；我们还使用 P-31-MRI 扫描通过测量无机磷酸盐和磷酸肌酸的浓度并计算无机磷酸盐与磷酸肌酸的比率 (Pi/PCr) 来研究足部肌肉的细胞代谢。 结果 所有三组中静息时的前臂 SHSIO2 均不同，对照组的值最高（平均 42 [SD 17]），其次是非神经性组（32 [8]）和神经性组（28） [8]) 组 (p
Background Changes in the large vessels and microcirculation of the diabetic foot are important in the development of foot ulceration and subsequent failure to heal existing ulcers. We investigated whether oxygen delivery and muscle metabolism of the lower extremity were factors in diabetic foot disease.Methods We studied 108 patients (21 control individuals who did not have diabetes, 36 patients with diabetes who did not have neuropathy, and 51 patients with both diabetes and neuropathy). We used medical hyperspectral imaging (MHSI) to investigate the haemoglobin saturation (SHSIO2; % of oxyhaemoglobin in total haemoglobin [the sum of oxyhaemoglobin and deoxyhaemoglobin]) in the forearm and foot; we also used P-31-MRI scans to study the cellular metabolism of the foot muscles by measuring the concentrations of inorganic phosphate and phosphocreatine and calculating the ratio of inorganic phosphate to phosphocreatine (Pi/PCr).Findings The forearm SHSIO2 during resting was different in all three groups, with the highest value in controls (mean 42 [SD 17]), followed by the non-neuropathic (32 [8]) and neuropathic (28 [8]) groups (p