PAIN REDUCTION BY FOCAL ELECTRICAL-STIMULATION OF BRAIN - ANATOMICAL AND BEHAVIORAL-ANALYSIS
PAIN REDUCTION BY FOCAL ELECTRICAL-STIMULATION OF BRAIN - ANATOMICAL AND BEHAVIORAL-ANALYSIS
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DOI：
10.1016/0006-8993(74)90534-4
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发表时间：
1974-01-01
期刊：
影响因子：
2.9
通讯作者：
LIEBESKIND, JC
中科院分区：
文献类型：
--
作者：
MAYER, DJ;LIEBESKIND, JC
这些实验研究了局部电刺激大脑产生的镇痛作用的几个方面。（1）镇痛作用的解剖学部位：只有刺激中脑中央灰质和脑室周围灰质，才能显著降低或完全消除对所有伤害性刺激的反应性。其他脑区的刺激增加跳跃阈值电击（隔核，丘脑背内侧核），有时甚至取消对组织破坏性捏（腹侧被盖，丘脑背内侧核）的反应，但从来没有消除对辐射热施加到尾巴。刺激丘脑腹侧基底复合体和下丘脑外侧区几乎不产生镇痛作用。（2）镇痛强度：在所有试验中，刺激中枢和脑室周围灰质产生的镇痛作用等于或大于10 mg/kg吗啡。（3）与奖赏的关系：发现刺激产生的镇痛与刺激的奖赏性质没有因果关系。镇痛作用通常是通过刺激不支持自我刺激行为的电极部位产生的;许多动物的自我刺激率很高，但没有镇痛作用。（4）与癫痫发作活动的关系：电图或明显的运动性癫痫发作活动与刺激产生的镇痛无关。(5)By与吗啡作用的部位和机制类似，提出了局灶性电刺激激活集中在脑室周围和导水管周围区域的疼痛抑制系统，并且其激活通过阻断伤害性信息通过脊髓的传递而至少部分地降低对伤害性刺激的反应性。
These experiments have examined several aspects of analgesia produced by focal electrical stimulation of the brain.(1)Anatomical locus of analgesic effects: only stimulation of the mesencephalic central gray matter and periventricular gray matter greatly reduced or totally abolished responsiveness to all noxious stimuli employed. Stimulation of other brain areas increased jump threshold to electric shock (septal nuclei, dorsomedial thalamic nucleus) and sometimes even abolished responsiveness to tissue destructive pinch (ventral tegmentum, dorsomedial thalamic nucleus), but never eliminated responding to radiant heat applied to the tail. Stimulation of the ventrobasal complex of the thalamus and the lateral hypothalamus produced little or no analgesia at all.(2)Magnitude of analgesia: stimulation of the central and periventricular gray matter produced analgesia equal to or greater than 10 mg/kg morphine on all tests.(3)Relationship to reward: stimulation-produced analgesia was found not to be causally related to the rewarding properties of the stimulation. Analgesia was often produced by stimulation at electrode sites which did not support self-stimulation behavior; and many animals self-stimulated at high rates but were not analgesic.(4)Relationship to seizure activity: electrographic or overt motor seizure activity was not related to stimulation-produced analgesia.(5)By analogy with the site and mechanism of morphine action, it is proposed that focal electrical stimulation activates a pain suppressive system concentrated in periventricular and periaqueductal regions and its activation reduces responsiveness to noxious stimuli, at least in part, by blocking transmission of nociceptive information through the spinal cord.