Photocatalytic Desulfonylative Homocoupling of Benzylic Sulfone Derivatives
Photocatalytic Desulfonylative Homocoupling of Benzylic Sulfone Derivatives
复制标题
苯甲基砜衍生物的光催化脱磺酰均偶联
DOI：
10.1055/a-1942-5695
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发表时间：
2022
期刊：
影响因子：
2
通讯作者：
Yim Jacky C.-H.
中科院分区：
文献类型：
--
作者：
Nambo Masakazu;Crudden Cathleen M.;Ohkura Ryusei;Ohtsuka Motoo;Yim Jacky C.-H.
描述了通过光氧化还原 Ir 催化剂进行苄基砜衍生物的脱磺酰化自偶联。 3,5-双(三氟甲基)苯基是该反应中磺酰基上的有效取代基，以良好的产率提供结构多样的多芳基化乙烷。可以通过α-官能化轻松制备的α-氘代或α-氟化砜也适用，这突出了合成医学上重要结构的途径。
A desulfonylative homocoupling of benzylic sulfone derivatives through a photoredox Ir catalyst is described. The 3,5-bis(trifluoromethyl)phenyl group is an effective substituent on sulfonyl group in this reaction, providing the structurally diverse multiply arylated ethanes in good yields. The α-deuterated or α-fluorinated sulfones, which can be readily prepared by α-functionalization, were also applicable, highlighting an avenue to synthesize medicinally important structures.