Possible role of macrophage mediated nonspecific cytotoxicity in tumour resistance.
Possible role of macrophage mediated nonspecific cytotoxicity in tumour resistance.
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巨噬细胞介导的非特异性细胞毒性在肿瘤抵抗中的可能作用。
DOI：
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发表时间：
1972
期刊：
影响因子：
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通讯作者：
J. Remington
中科院分区：
文献类型：
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作者：
J. Hibbs;L. H. Lambert;J. Remington
除了在特异性肿瘤免疫中的作用1-3之外，巨噬细胞似乎是介导小鼠对细胞内生物体的特异性和非特异性抵抗力的效应细胞4-7，关键因素是活化巨噬细胞群的发展，这些巨噬细胞能够抵抗细胞内病原体的破坏并能够消灭细胞内病原体4,8。由于对肿瘤的抵抗力似乎主要是细胞介导的，因此我们研究了慢性细胞内原虫感染所赋予的非特异性细胞介导的抵抗力是否提供了针对肿瘤的保护。这些感染赋予了对多种本土和可移植小鼠肿瘤的抵抗力9,10。由于原生动物感染小鼠对肿瘤和无关感染因子的抵抗机制可能相似，因此评估了活化的巨噬细胞对靶细胞的影响。结果表明，长期感染弓形虫的小鼠的腹腔巨噬细胞具有通过非吞噬机制在体外非特异性破坏靶细胞的能力。
IN addition to their role in specific tumour immunity1–3, macrophages seem to be the effector cells in mediating specific and nonspecific resistance to intracellular organisms in mice4–7, the critical factor being the development of a population of activated macrophages which resist destruction by and are able to destroy intracellular pathogens4,8. Because resistance to neoplasia seems to be primarily cell mediated, we have investigated whether the nonspecific cell-mediated resistance conferred by chronic intracellular protozoal infection provides protection against tumours. These infections conferred resistance to a variety of autochthonous and transplantable murine tumours9,10. Since the mechanism of resistance to tumours and unrelated infectious agents in the protozoan-infected mice might be similar, the effect of activated macrophages on target cells was evaluated. The results demonstrated that peritoneal macrophages from mice chronically infected with Toxoplasma have the capacity to non-specifically destroy target cells in vitro by a nonphagocytic mechanism.